Animal models

The use of human cancer tissue or cell lines grown as xenografts in immunodeficient mice has been a standard test for evaluating cancer management techniques.

In these studies the cancer cells are implanted into immunodeficient mice and form tumors. These tumors can then be treated with novel therapies and the growth and metastasis of the tumor used to measure the efficacy of the treatment.

LECR is experienced in a wide variety of orthotopic and metastatic tumor models in immunodeficient and immunocompetent hosts. The primary imaging modality is luciferase-based but can be extended to ultrasound, MRI, PET, and CT imaging.