Release of NO and EDFH from endothelial cells.

A first research topic focuses on substances released from endothelial cells, more specifically NO and the as yet unknown endothelium derived hyperpolarizing factor (EDHF). Our present studies aim to unravel the role of different isoforms of soluble guanylyl cyclase (sGC) in relaxations mediated by NO (all or not endothelium-dependent), NO-donors and in relaxations elicited by direct sGC activators. Similar in vitro research is also done on isolated corpora cavernosa in face of the increasing problem of erectile dysfunction. Erection, which is mainly elicited by NO from NANC nerves, is also studied in vivo. This research uses genetic modified mice with one or more dysfunctional isoforms of sGC. In parallel also research is done on CO and CO-donors.