Lezing 'Metabolism at the crossroads of Inflammation and Immunity: Lessons from Salmonella Typhimurium'

Voor wie
Studenten, Medewerkers, Alumni, Bedrijven
Wanneer
30-11-2017 van 14:00 tot 15:30
Waar
UGent-VIB-onderzoeksgebouw, Technologiepark 927, 9052 Zwijnaarde
Voertaal
Engels
Door wie
VIB-UGent Center for Inflammation Research (GE01/WE14/WE10)
Contact
coordination@irc.vib-ugent.be
Website
http://www.irc.ugent.be/index.php?id=seminars
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Nirmal Robinson (CECAD Research Center, University of Cologne) explains how S. Typhimurium research can be used to treat a variety of human diseases.

Using Salmonella Typhimurium as a model pathogen, we have deciphered that molecules such as Sirtuins which lie at the interface between metabolism and immunity play a significant role in regulating inflammation and cell-autonomous immunity. Our investigations further reveal that basic metabolic pathways such as glycolysis are required for phagosome maturation and clearance of pathogens by macrophages. Our findings highlight that understanding key molecular and cellular mechanisms of pathogen-host interactions would lead to new general concepts which can be exploited to treat a variety of human pathologies.