Lezing 'A nuclear brake on T-cell factors/Lef1 transcriptional activation switches off Wnt/β-catenin signaling'

Voor wie
Studenten, Medewerkers, Alumni, Bedrijven
01-03-2018 van 14:00 tot 14:45
UGent-VIB-onderzoeksgebouw, Technologiepark 927, 9052 Zwijnaarde
Door wie
Department of Biomedical Molecular Biology, Faculty of Sciences.
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Dr. Béatrice C. Durand (Institut Curie, Université Paris Sud, Orsay) will describe a novel molecular mechanism regulating the Wnt signaling pathway

The Wnt pathway plays major roles in development, stem cell biology, regeneration, and tumorigenesis. Wnt modulates gene transcription through stabilization of the nuclear effector ß-catenin. In most biological contexts, ß-catenin mediates transcriptional activation via de-repression of the transcription factor Tcf/Lef1, which in absence of Wnt, binds to the co-repressor Groucho. Dr. Durand has found a novel mechanism by which the transcription factor Barhl2 inhibits Wnt dependent transcription involved in early development, forebrain proliferation, and formation of post-embryonic neural progenitor germinative zones. Furthermore Barhl2, and Barhl1 its closest homologue, participate in the emergence of medulloblastoma, a pediatric tumour of cerebellar origin. Her results provide a new framework to comprehend how ß-catenin elicits specific transcriptional responses, and give cues on how Barhl proteins could contribute to cerebellar tumorigenesis.

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