Lezing 'T-cell receptor repertoire diversity and AT-DNA sensing by innate immune cells as key features in controlling neurological varicella-zoster virus infection'

Voor wie
Studenten, Medewerkers, Alumni, Bedrijven
08-06-2018 van 11:30 tot 12:45
UGent-VIB-onderzoeksgebouw, Technologiepark 927, 9052 Zwijnaarde
Door wie
VIB-UGent Center for Inflammation Research (GE01/WE14/WE10)
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Ogunjimi Benson will explain his work on T-cells in neurological Varicella-zoster virus infection.

Ogunjimi Benson from Antwerp Center for Translational Immunology and Virology (ACTIV), Vaccine & Infectious Disease Institute (VAXINFECTIO) – University of Antwerp, Division of Paediatric Rheumatology, Antwerp University Hospital, Belgium is our guest speaker.
Varicella-zoster virus (VZV) causes chickenpox in children and remains latent in neural ganglia afterwards. However, VZV reactivation causes herpes zoster later in life. In this seminar, I will present our most recent data on the pathophysiology of “neuro-VZV”.
I will first discuss how our HLA affinity modeling and T-cell receptor (TCR) repertoire data indicate that recognition of VZV-antigens by CD8+ T-cells are likely a key feature in preventing VZV reactivation.
Next, I will present patient-derived data on how the detection of AT-DNA (abundant in VZV) by RNA polymerase III in innate immune cells is a key factor in preventing neurological complications of chickenpox.