Lezing 'The role of IL-23/IL-17 immune pathway in inflammatory arthritis'

Voor wie
Studenten, Medewerkers, Alumni, Bedrijven
28-09-2018 van 11:30 tot 12:45
UGent-VIB-onderzoeksgebouw, Technologiepark 927, 9052 Zwijnaarde
Door wie
VIB-UGent Center for Inflammation Research (GE01/WE14/WE10)
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Dr. Eric Lubberts, Dept. of Rheumatology, Laboratory of Immune-Mediated Inflammatory Diseases, Eramus MC Rotterdam IL-23/Il17 immune pathway arthritis

The discovery of the IL-23/IL-17 immune pathway has changed immunology and the concept of many immune-mediated inflammatory diseases. T helper 17 (Th17) cytokines provide protective immunity to infections by fungi and extracellular bacteria but also are involved in the development of immune-mediated inflammatory diseases. Memory CD4+CCR6+ T cells are a major source of IL-17 and is a heterogeneous group of cells, containing multiple subpopulations including Th17, Th17/Th1 and Th17.1 cells. Here I will give an overview of the fundamentals how the IL-23/IL-17 axis and Th17 cytokines contributes to joint inflammation and destruction. Furthermore, I will discuss the functional role of the individual human CCR6+ memTh subpopulations in their capacity to activate synovial fibroblasts of patients with rheumatoid arthritis and show the effects of vitamin D to regulate the function of these cells.