Lezing 'Signalling by small GTPases : from allosteric regulation to inhibition by small molecules'

Voor wie
Studenten, Medewerkers, Alumni, Bedrijven
16-10-2018 van 14:00 tot 15:15
UGent-VIB-onderzoeksgebouw, Technologiepark 927, 9052 Zwijnaarde
Door wie
VIB-UGent Center for Inflammation Research (GE01/WE14/WE10)
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Prof. Jacqueline Cherfils, Laboratoire de Biologie et Pharmacologie Appliquée, CNRS and Ecole Normale Supérieure Paris-Saclay signalling small GTPases

Lipidated small GTPases assemble signaling platforms at the periphery of intracellular membranes, and their deregulation is associated with cancers and many other diseases. Guanine nucleotide exchange factors (GEFs), which activate small GTPase by stimulating GDP/GTP exchange, are key players in these processes. However, an integrated understanding of the contribution of the lipid bilayer to the efficiency and specificity of small GTPases machineries is still lacking. My lab addresses this question by combining structural biology, reconstitution of purified proteins in artificial membranes and interference by small molecules. I will present recent studies that illustrate the allosteric regulation of small GTPases and their GEFs by membranes and open new routes for their inhibition by small molecules.