Lezing 'The multiple roles of Endoplasmic Reticulum lipid metabolism in development and in disease'

Voor wie
Studenten, Medewerkers, Alumni, Bedrijven
25-01-2019 van 11:30 tot 12:45
UGent-VIB-onderzoeksgebouw, Technologiepark 927, 9052 Zwijnaarde
Door wie
VIB-UGent Center for Inflammation Research (WE14, WE10, GE35)
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Rose Goodchild (FDR Chair for Dystonia Research, VIB-KU Leuven Center for Brain & Disease Research, Leuven) is our guest. Registration is not needed.

The endoplasmic reticulum (ER) houses the core enzymes of lipid biogenesis that produce triglycerides (“fat”), as well as membrane lipids. These processes are tightly connected to physiological events like cell growth and energy storing, and must be differentially regulated in different cell types and developmental contexts. Our group works on the torsin-family of ER resident ATPases that are essential in animals, and also underlie a series of human neurological diseases. We have uncovered that the torsins are evolutionarily conserved regulators of lipid metabolism. We have now shown the same lipid metabolic abnormalities in the brains of neurological disease models, shown that abnormal lipid metabolism is responsible for hallmark neurological dysfunction in mice, and shown that we can suppress defects including lethality. These data emphasise the value for human disease of studying fundamental cell biological events across diverse organisms and cellular systems.