Lezing 'A gut feeling about the brain: understanding and preventing the cognitive impairment of preterm infants with necrotizing enterocolitis'

Voor wie
Studenten, Medewerkers, Alumni, Bedrijven
14-06-2019 van 11:30 tot 12:45
UGent-VIB-onderzoeksgebouw, Technologiepark 71, 9052 Zwijnaarde
Door wie
VIB-UGent Center for Inflammation Research (WE14, WE10, GE35)
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David J. Hackam (Johns Hopkins University School of Medicine) will show how a severe gastrointestinal disease is linked to impaired brain function.

Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease of the premature infant. One of the most important long-term complications observed in children who survive NEC early in life is the development of profound neurological impairments. However, the pathways leading to NEC-associated neurological impairments remain unknown, thus limiting the development of prevention strategies. We have recently shown that NEC development is dependent on the expression of the lipopolysaccharide receptor Toll-like receptor 4 (TLR4) on the intestinal epithelium, whose activation by bacteria in the newborn gut leads to mucosal inflammation.
Our findings shed light on the molecular pathways leading to the development of NEC-associated brain injury, provide a rationale for early removal of diseased intestine in NEC, and indicate the potential of targeted therapies that protect the developing brain in the treatment of NEC in early childhood.
Registration for this seminar is not required.