Lezing 'Developmental Programming of Tissue-Resident Macrophages'

Voor wie
Alumni , Bedrijven , Medewerkers , Studenten
09-12-2022 van 11:30 tot 12:30
UGent-VIB-onderzoeksgebouw, Technologiepark 71, 9052 Zwijnaarde
Door wie
VIB-UGent Center for Inflammation Research

This talk will discuss how macrophages can transmit the maternal obese metabolic state to the next generation.

Prof Elvira Mass (Life & Medical Sciences(LIMES) Institute, University of Bonn, Germany) is our guest speaker. More information on her talk:

The global epidemic of obesity has led to an increasing number of obese women in childbearing age. Maternal obesity may have harmful consequences on fetal and adult metabolic programming, however, the underlying mechanisms remain elusive. Macrophages have been identified as metabolite-sensing cells and important mediators of pathological conditions caused by intake of a western diet. The recent discovery that most tissue macrophages have a fetal origin places these cells in a unique position of sensing and responding to metaflammation during embryogenesis. Using a maternal obesity mouse model, we investigate how Kupffer cells contribute to the fatty liver phenotype in the offspring.

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