Activation of the ERK1/2 signalling molecule by the gE glycoprotein of pseudorabies virus

Maria Setas Lopes Pontes
Faculteit Diergeneeskunde
Vakgroep Virologie, Parasitologie en Immunologie
Maria José Setas Lopes Pontes was born in Mirandela, Portugal, on 17th of October 1986. In 2004, Maria entered University of Minho, Braga, Portugal, graduating in 2008 with a Master degree in Applied Biology. For her master thesis research, Maria attended Wageningen University & Research (WUR), Wageningen, The Netherlands. She continued her research at the same institution after graduating, as a research assistant. In September 2009, Maria enrolled in the Doctoral Program of Ghent University, Ghent, Belgium. Her research around the effects of pseudorabies glycoprotein E on the ERK1/2 signalling pathway resulted in two first author peer-reviewed papers published in international journals. During her research time, Maria presented her work, both via poster- and oral- presentation, at national and international congresses.
Academische graad
Doctor in de diergeneeskundige wetenschappen
Taal proefschrift
Prof. Dr. Herman Favoreel Faculteit Diergeneeskunde, UGent
Prof. Dr. Filip Van Immerseel Faculteit Diergeneeskunde, UGent Voorzitter van de examencommissie Dr. N. De Regge Enzootic and (re)emerging diseases CODA-CERVA Prof. Dr. Bruno Verhasselt Faculteit Geneeskunde, UGent Prof. Dr. H. Nauwynck, DVM Faculteit Diergeneeskunde, UGent Dr. B. Devriendt Faculteit Diergeneeskunde, UGent

Korte beschrijving

The glycoprotein E (gE), an envelope protein conserved amongst the Alphaherpesvirinae subfamily members, has been credited with multiple functions throughout the years. The role of gE in virulence, viral intercellular and neuronal spread, virion assembly, species-specific Fcγ receptor-like activity and antibody-induced capping has been reported by several authors, including our group. Herpesviruses are highly competent in manipulating cellular signalling cascades to their advantage. The ERK1/2 MAPK signalling pathway, a central signalling cascade, represents a particularly attractive target for viruses since this signalling axis controls various fundamental cellular events.


Donderdag 15 februari 2018, 17:00
Auditorium D, Salisburylaan 133, 9820 Merelbeke

After the defence there will be a small reception to which you are cordially invited to attend.