Thermoplastic polyurethanes for the manufacturing of high drug loaded sustained release matrices

Glenn Verstraete
Faculteit Farmaceutische Wetenschappen
Vakgroep Geneesmiddelenleer
Master of Pharmaceutical Sciences (Cum Laude), Ghent University, 2012-2014 Bachelor of Pharmaceutical Sciences, Ghent University, 2009-2012 Industrial Sciences, VTI Ieper, 2003-2009
Academische graad
Doctor in de farmaceutische wetenschappen
Taal proefschrift
Vertaling titel
Thermoplastische polyurethanen voor de aanmaak van hoog gedoseerde matrices met vertraagde vrijstelling
Prof. dr. Chris Vervaet, UGent-Geneesmiddelenleer - Prof. dr. em. Jean Paul Remon, UGent-Geneesmiddelenleer
Prof. dr., Thomas De Beer, UGent-Farmaceutische Analyse - Prof. dr., Koen Raemdonck, UGent-Geneesmiddelenleer - Prof., Guy Van den Mooter, KULeuven - Prof., Filip Kiekens, UA - Prof., Richard Hoogenboom, Ugent-Faculteit Wetenschappen - Prof., Juergen Siepmann, Université Lille Nord de France

Korte beschrijving

Sustained release formulations are launched by companies to extend the exclusivity of its proprietary product. It is a form of life-cycle management for the drug as it nears patent expiration. As well as strategic advantages, the development of sustained release formulations has patient-oriented advantages as they improve patient compliance, optimize the pharmacokinetic profile, reduce side effects and meet clinical needs. Hot-melt extrusion (HME) is a continuous, robust, solvent-free and fast manufacturing process which has shown a lot of potential for the development of sustained release formulations. Although a lot of sustained release matrices have been successfully developed via HME, the drug load in these formulations is often low (


Dinsdag 20 februari 2018, 18:30
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