Thermoplastic polyurethanes for the manufacturing of high drug loaded sustained release matrices

Promovendus/a
Glenn Verstraete
Faculteit
Faculteit Farmaceutische Wetenschappen
Vakgroep
Vakgroep Geneesmiddelenleer
Curriculum
Master of Pharmaceutical Sciences (Cum Laude), Ghent University, 2012-2014 Bachelor of Pharmaceutical Sciences, Ghent University, 2009-2012 Industrial Sciences, VTI Ieper, 2003-2009
Academische graad
Doctor in de farmaceutische wetenschappen
Taal proefschrift
en
Vertaling titel
Thermoplastische polyurethanen voor de aanmaak van hoog gedoseerde matrices met vertraagde vrijstelling
Promotor(en)
Prof. dr. Chris Vervaet, UGent-Geneesmiddelenleer - Prof. dr. em. Jean Paul Remon, UGent-Geneesmiddelenleer
Examencommissie
Prof. dr., Thomas De Beer, UGent-Farmaceutische Analyse - Prof. dr., Koen Raemdonck, UGent-Geneesmiddelenleer - Prof., Guy Van den Mooter, KULeuven - Prof., Filip Kiekens, UA - Prof., Richard Hoogenboom, Ugent-Faculteit Wetenschappen - Prof., Juergen Siepmann, Université Lille Nord de France

Korte beschrijving

Sustained release formulations are launched by companies to extend the exclusivity of its proprietary product. It is a form of life-cycle management for the drug as it nears patent expiration. As well as strategic advantages, the development of sustained release formulations has patient-oriented advantages as they improve patient compliance, optimize the pharmacokinetic profile, reduce side effects and meet clinical needs. Hot-melt extrusion (HME) is a continuous, robust, solvent-free and fast manufacturing process which has shown a lot of potential for the development of sustained release formulations. Although a lot of sustained release matrices have been successfully developed via HME, the drug load in these formulations is often low (

Praktisch

Wanneer
Dinsdag 20 februari 2018, 18:30
Waar
Auditorium 2, Ottergemsesteenweg 460, 9000 Gent