The development of a continuous and controlled freeze-drying concept for biopharmaceutical unit doses

Pieter-Jan Van Bockstal
Faculteit Farmaceutische Wetenschappen
Vakgroep Farmaceutische Analyse
Master of Science in Drug Development, Ghent University, 2011 - 2013: Bachelor of Science in Pharmaceutical Sciences, Ghent University, 2008 - 2011 Degree Sciences - Mathematics, Sint-Lodewijkscollege, Lokeren, 2006 - 2008 Degree Sciences - Mathematics, Sint-Teresiacollege, Eksaarde (Lokeren), 2002 - 2006
Academische graad
Doctor in de farmaceutische wetenschappen
Taal proefschrift
Vertaling titel
De ontwikkeling van een continu en gecontroleerd vriesdroogconcept voor biofarmaceutische eenheidsdosissen
Prof. dr., Thomas De Beer, UGent-Farmaceutische Analyse
Prof. dr., Stefaan De Smedt, UGent-Geneesmiddelenleer - Prof. dr., Chris Vervaet, UGent-Geneesmiddelenleer - Prof. dr., Ingmar Nopens, UGent-Faculteit Bio-ingenieurswetenschappen - Prof. dr., Stéphanie Passot, AgroParis Tech - Dr., Erwan Bourles, GSK - Dr., Raf De Dier, ITS-JNJ

Korte beschrijving

Freeze-drying is a well-established formulation technique to improve the stability of biopharmaceuticals which are unstable in aqueous solution. Conventional pharmaceutical freeze-drying is a batch-wise process during which all vials are processed through a sequence of consecutive steps, i.e., freezing, primary drying and secondary drying, until the dried end product is obtained. However, this inefficient batch approach is inherently associated with several disadvantages, leading to an uncontrolled variability in product quality, which goes against the guidelines issued by the regulatory authorities. Therefore, the main objective of this thesis was to develop and evaluate a continuous and controlled freeze-drying concept for pharmaceutical unit doses, resolving the disadvantages related to the current state-of-the-art batch process.


Dinsdag 27 februari 2018, 18:00
Auditorium 2, Ottergemsesteenweg 460, 9000 Gent