Protecting chickens against Campylobacter jejuni by Camelidae-derived nanobodies

Charlotte Vanmarsenille
Faculteit Diergeneeskunde
Vakgroep Pathologie, Bacteriologie en Pluimveeziekten
Charlotte Vanmarsenille obtained her Master in Bioengineering Sciences at the VUB. Subsequently she started a joint PhD in the research groups of Structural Biology Brussels and of Viral Genetics at the VUB and in the Department of Pathology, Bacteriology and Avian Diseases at Ghent University. Her research resulted in a first author publication in a peer reviewed journal and she presented her research at national and international conferences in poster presentations. She has supervised eight master theses and was involved in the laboratory course Microbiology and Gene Technology. The project was funded by the Federal Public Service Health, Food Chain Safety and Environment.
Academische graad
Doctor in de Diergeneeskundige wetenschappen
Taal proefschrift
Prof. Dr. Henri De Greve Prof. Dr. Frank Pasmans (Ghent University)
Prof. Dr. Daniël Charlier (chairman) Prof. Dr. Niek Sanders (secretary, Ghent University) Prof. Dr. Jean-Pierre Hernalsteens (co-promoter) Prof. Dr. An Martel (co-promoter, Ghent University) Prof. Dr. ir. Geert Angenon Prof. Dr. Peter Geldhof (Ghent University) Prof. Dr. Delphine Martiny (CHUB-ULB) Dr. Geertrui Rasschaert (ILVO)

Korte beschrijving

Worldwide, Campylobacter is the most prevalent cause of foodborne infections in humans. Observed symptoms range from diarrhoea to neurological disorders and have a severe health burden as result. C. jejuni and C. coli are the two most common zoonotic species involved in human infections. Broiler chickens are the primary source for transmission. Infections are mostly due to consumption or handling of contaminated poultry meat. Control strategies that impede the colonization of poultry by Campylobacter, can be effective in reducing Campylobacter-related infections in humans. Despite major health issues and high societal costs associated with campylobacteriosis, efficient mitigation is not available and therefore novel control measures are required. In this context, we developed a passive immunization strategy, using Campylobacter-specific nanobodies, that has the potential to control colonization of chickens.


Maandag 26 maart 2018, 17:00
Auditorium D.2.01 - Campus Humanities, Sciences and Engineering VUB, Pleinlaan 2, 1050 Elsene