The weight of obesity on kidney health in dogs assessed by markers of kidney function and injury, and by contrast-enhanced ultrasonography

Daisy Liu
Faculteit Diergeneeskunde
Vakgroep Medische Beeldvorming van de Huisdieren en Orthopedie van de Kleine Huisdieren
Daisy Liu was born on 4 December 1983 in San Francisco, California, USA. She received her Bachelor of Science with a major in animal science and a minor in nutrition from the University of California in Davis in 2006. Afterwards, she studied veterinary medicine at Ghent University where she obtained her master’s degree in Veterinary Science with distinction in 2011. In 2012, she was awarded a 2-year fellowship-training grant from the Morris Animal Foundation to study the relationship between gut microbiota and obesity in dogs at the Laboratory of Animal Nutrition, Faculty of Veterinary Medicine, Ghent University. In 2015, she started her doctoral research at the Department of Medical Imaging of Domestic Animals and Orthopedics and the Department of Animal Nutrition, Genetics and Ethology. The project, funded by the Special Research Fund of Ghent University, focused on the effect of weight gain and weight loss on renal function, injury and perfusion using novel kidney markers and contrast-enhanced ultrasound in dogs. She has authored and co-authored several publications in international scientific journals. She also presented her work at national and international conferences.
Academische graad
Doctor in de Diergeneeskundige wetenschappen
Taal proefschrift
Prof. dr. K. Vanderperren Faculty of Veterinary Medicine, Ghent University Prof. dr. M. Hesta Faculty of Veterinary Medicine, Ghent University
Prof. dr. H. de Rooster Chairman of the Examination Committee Faculty of Veterinary Medicine, Ghent University Prof. dr. D. Paepe Faculty of Veterinary Medicine, Ghent University Dr. J. Debraekeleer Tienen, Belgium Prof. dr. E. Meyer Faculty of Veterinary Medicine, Ghent University Prof. dr. W. De Spiegelaere Faculty of Veterinary Medicine, Ghent University Prof. dr. Marianne Diez Faculty of Veterinary Medicine, University of Liège

Korte beschrijving

In humans, obesity is a risk factor for chronic kidney disease (CKD). Initially, obesity increases renal perfusion and glomerular filtration rate (GFR). It is followed by proteinuria, progressive glomerulosclerosis, and a reduction of the renal microvasculature. Obesity's effect on the kidney in dogs has not been studied extensively yet. In the dog model of human obesity-related kidney disease, rapidly inducing obesity causes similar functional and structural changes in the kidney as seen in humans. However, at which point these changes occur during obesity development and if they can be reversed with weight-loss has not been studied in the same individual yet. Furthermore, sensitive, non-invasive techniques to detect early obesity-related changes in the kidney are still lacking.


Maandag 17 december 2018, 17:00
Auditorium A, Salisburylaan 133, 9820 Merelbeke

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