A step forward in oral vaccine design: Aminopeptidase N-targeted antibody formats as carriers for oral vaccines subunits in pigs

Promovendus/a
Raquel Sanz García
Faculteit
Faculteit Diergeneeskunde
Vakgroep
Vakgroep Virologie, Parasitologie en Immunologie
Curriculum
Raquel Sanz García was born the 25th of July 1988 in Córdoba, Spain. In 2006 she finished her secondary studies in the ‘Instituto de Enseñanza Secundaria Séneca’, Córdoba. She followed her 5-years degree in Veterinary Medicine in the Faculty of Veterinary, University of Córdoba. During her studies she followed multiple trainings in different veterinary clinics and she was a collaborator student of the Department of Anesthesiology and Surgery. In 2011, she obtained her degree in Veterinary Medicine and she received a grant to do a fellowship in the Stiftung Tierärztliche Hochschule Hannover in Germany. During the next two years, she worked as a veterinarian and followed another degree in Food Science and Technology at the University of Córdoba, which she finished in 2013. In 2014 she finished her Master in Food Safety and Quality Control in the University of León, Spain. Her scientific research started in April 2014, when she moved to Belgium to follow an internship in the Research Institute for Agriculture, Fisheries and Food (ILVO), where she worked in the development of food allergy tests. In February 2015, she started her PhD in Veterinary Science in the Laboratory of Immunology of the Faculty of Veterinary, University of Gent, Belgium. During 5 years, she worked in the development of oral vaccine strategies for pigs under the lead of Prof. Dr. Cox and Dr. Devriendt. Raquel has collaborated in several scientific research studies and is author or co-author of peer-reviewed publications.
Academische graad
Doctor in de diergeneeskundige wetenschappen
Taal proefschrift
Engels
Promotor(en)
Prof. dr. Eric Cox - Dr. Bert Devriendt, Faculty of Veterinary Medicine, UGent
Examencommissie
Prof. dr. Dominiek Maes, Faculty of Veterinary Medicine, UGent - Prof. dr. Gregers Jurgensen, SSI, Center for Vaccine Research, Copenhagen - Prof. dr. Jan Paeshuyse, Faculty of Bioscience Engineering, KULeuven - Emeritus Prof. dr. Bruno Goddeeris, Faculty of Bioscience Engineering, KULeuven - Prof. dr. Xavier Saelens, VIB-UGent, Center for Medical Biotechnology, Gent - Dr. Evy Goossens, Faculty of Veterinary Medicine, UGent

Korte beschrijving

Gastrointestinal infections causing diarrhea remain one of the most common causes of morbidity and mortality in neonatal and recently weaned piglets, with associated economic losses. Moreover, these infections are one of the main causes of illness and death in under-5 children in low resource countries. Antibiotics and feed additives have been widely used to control these infections in farm animals. However, due to the increasing bacterial resistance, the EU banned the prophylactic use of antibiotics and some feed additives, such as zinc oxide. Consequently, many efforts have focused on the development of effective vaccines to prevent these infections. Nevertheless, most commercialized vaccines are delivered systemically and they fail to induce protective intestinal immunity. Contrary, mucosal vaccines have been shown to induce pathogen-specific IgA at the site of infection, which can lead to an efficient protective immune response. Unfortunately, the development of oral vaccines remains a challenge due to the presence of the gut epithelial barrier and the harsh gastrointestinal environment. In addition, oral vaccines have to circumvent the dominant mucosal tolerogenic immune response which protects the host from exaggerated reactions to for instance food antigens.

Praktisch

Wanneer
Vrijdag 10 juli 2020, 14:00
Waar
Faculteit Diergeneeskunde, Salisburylaan 133, 9820 Merelbeke

Due to COVID-19 measures, the public defense will take place via live-stream. This thesis contains confidential information and thus, an agreement of confidentiality must be signed in advance to obtain permission to attend the public defense via an MS Teams meeting. Participants will receive this document following registration. If you wish to participate, please register before 5 July by E-mail to Raquel.SanzGarcia@Ugent.be