ADVANCES IN CANINE EPILEPSY TREATMENT FROM ORAL TO INTRANASAL AND TRANSCRANIAL

Promovendus/a
Marios Charalambous
Faculteit
Faculteit Diergeneeskunde
Vakgroep
Vakgroep Kleine Huisdieren
Curriculum
Marios Charalambous was born on 14th February 1988 in Athens, Greece. Marios Charalambous graduated from the Aristotle University of Thessaloniki (Greece) in 2010. After completing his small animal rotating internship at Queen's Veterinary School Hospital at the University of Cambridge (UK), he worked in general and emergency private practice in the UK and also completed a human-based post-graduate Diploma in Advanced Neuroimaging at the University College London (UCL), Institute of Neurology (UK), with primary research project the use of pre-surgical neuroimaging techniques for detecting the epileptogenic zone in humans eligible for epilepsy surgery. Marios Charalambous worked and completed his initial training in Neurology at Cornell University (USA) before joining Ghent University (Belgium) in September 2016 as Neurology resident in a program approved by the American College of Veterinary Internal Medicine (ACVIM) and European College of Veterinary Neurology (ECVN) and as a doctoral student. Marios Charalambous has a strong academic background and significant research interest in the field of epilepsy treatment. Marios Charalambous participated in multiple training programs and courses hold by Universities within the UK and USA, all with strong neurology service. He achieved the ESVPS post-graduate Certificate in Neurology after attending courses, writing thesis and passing exams. He was recognized as a Chartered Scientist by the Science Council (UK) and as a Fellow of the Higher Education Academy (FHEA). He is also the past representative of the European Society of Veterinary Neurology (ESVN)
Academische graad
Doctor in de diergeneeskundige wetenschappen
Taal proefschrift
Engels
Promotor(en)
Prof. dr. Luc Van Ham, Faculty of Veterinary Medicine, Ghent University, Belgium - Dr. Sofie Bhatti, Faculty of Veterinary Medicine, Ghent University, Belgium - Prof. dr. Holger Volk, University of Veterinary Medicine, Hannover, Germany
Examencommissie
Prof. dr. S. De Vliegher, Faculty of Veterinary Medicine, Ghent University, Belgium - Prof. dr. M. Berendt, University of Copenhagen, Denmark - Dr. P. Mandigers Utrecht University, The Netherlands - Prof. dr. P. Boon, Ghent University Hospital, Ghent University, Belgium - Prof. dr. C. Delesalle, Faculty of Veterinary Medicine, Ghent University, Belgium - Dr. T. Bosmans, Faculty of Veterinary Medicine, Ghent University, Belgium

Korte beschrijving

Epilepsy is the most common chronic neurological disorder in dogs. Oral antiepileptic drugs (AEDs) are the cornerstone of chronic management of canine epilepsy. However, in particular circumstances such as occurrence of multiple or severe adverse reactions to AEDs, multi-drug tolerance (pharmaco-resistant epilepsy) and emergency epileptic seizures (status epilepticus), oral AEDs might prove inadequate or fail to control the epileptic seizures. The scientific aims of this PhD were to provide thorough evidence with regards to the efficacy and safety of the commonly used AEDs in canine epilepsy as well as to evaluate and introduce new potentially more effective and safer treatment options in circumstances where oral AEDs cannot control the epileptic seizures, such as in status epilepticus (SE) and pharmaco-resistant epilepsy. Towards this goal, two systematic reviews and meta-analysis were conducted in order to evaluate the literature by using explicit methods to systematically search, critically appraise and statistically assess the results of multiple primary studies related to the efficacy and safety of AEDs in canine epilepsy. Two openlabelled randomized controlled studies were conducted to evaluate a new parenteral first-line benzodiazepine administration route (intranasal) for the management of canine SE at out-of- and within-hospital settings, particularly when there is no intravenous (IV) access, and compare this to the most commonly used non-IV parenteral route (rectal) as well as the “gold-standard” IV route. Lastly, a single-blinded randomized placebocontrolled study was conducted to introduce and assess a new non-invasive neurostimulation management option (repetitive transcranial magnetic stimulation) for dogs with pharmaco-resistant epilepsy.

Praktisch

Wanneer
Vrijdag 18 september 2020, 17:00
Waar
Het Pand, zaal Refter, Onderbergen 1, 9000 Gent

If you would like to attend please register no later than September 11 via e-mail at marios.charalambous@ugent.be