Prevalence and virulence potential of ‘gang of five’ Shiga toxin-producing Escherichia coli (STEC) on dairy cattle farms and assessment of heterologous vaccination to reduce faecal excretion of STEC O26:H11 in calves

Promovendus/a
Engelen, Frederik
Faculteit
Faculteit Diergeneeskunde
Vakgroep
Vakgroep Virologie, Parasitologie en Immunologie
Curriculum
Frederik Engelen was born on December 5th, 1992 in Turnhout, Belgium. In 2016, he obtained his master’s degree in Pharmaceutical Sciences (Minor Drug Development) from the Catholic University of Leuven (KUL), Belgium. Following his graduation, he started his doctoral studies in December 2016 at the Laboratory of Immunology, Faculty of Veterinary Medicine, Ghent University (UGent), Belgium. His work focused on the occurrence of Shiga toxin-producing Escherichia coli (STEC) on Belgian dairy cattle farms and evaluation of vaccination as a potential strategy to reduce bovine STEC excretion in calves. Frederik is author of several publications in peer-reviewed international journals, of which two he is first author. He participated in several (inter-) national scientific conferences and obtained the Doctoral Training Programme certificate of the Ghent University Doctoral Schools.
Academische graad
Doctor in de diergeneeskundige wetenschappen
Taal proefschrift
Engels
Promotor(en)
Prof. dr. E. Cox, Faculty of Veterinary Medicine, Ghent University - Prof. dr. L. De Zutter, Faculty of Veterinary Medicine, Ghent University - Prof. dr. J.G. Mainil, Faculty of Veterinary Medicine, University of Liège - Dr. B. Devleesschauwer, Faculty of Veterinary Medicine, Ghent University; Sciensano, Brussels
Examencommissie
Prof. dr. G. Opsomer, Chairman, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium - dr. F. Boyen, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium - Prof. dr. M. Heyndrickx, Institute of Agricultural and Fisheries Research (ILVO), Melle, Belgium - dr. B. Verhaegen, Sciensano, Brussels, Belgium dr. T.N. McNeilly, Moredun Research Institute, Penicuik, Midlothian, Scotland

Korte beschrijving

Shiga toxin-producing E. coli (STEC) are important zoonotic foodborne pathogens causing acute and bloody diarrhoea, potentially progressing to the life-threatening haemolytic-uremic syndrome (HUS). Cattle represent the major natural reservoir and asymptomatically carry STEC in their gastro-intestinal tract, resulting in faecal excretion of these pathogens. Consequently, human infection occurs predominantly through ingestion of food and/or water contaminated with bovine faeces. STEC are characterized by their ability to produce Shiga toxins 1 and/or 2 (Stx1, Stx2). In addition, most STEC strains associated with severe human disease also possess the locus of enterocyte effacement (LEE) pathogenicity island, encoding the outer membrane adhesin intimin (eae), its translocated intimin receptor (Tir), a type three secretion system (T3SS) and several translocated effector molecules, responsible for the formation of characteristic attaching-effacing (A/E) lesions which mediate intimate attachment of STEC to the intestinal mucosa. Over 400 STEC serotypes have been identified to date, but only a limited number have been associated with human pathogenicity. While STEC O157:H7 is the serotype most frequently associated with severe human illness, several non-O157 serotypes have emerged over the last decades as important pathogens. Since effective treatments for STEC infections in humans are currently non-existent, the development of interventions aimed at reducing the occurrence of STEC in its bovine reservoir has received considerable attention over the last decades.

Praktisch

Datum
Maandag 3 mei 2021, 14:00
Locatie
Diergeneeskunde, Salisburylaan 133, 9820 Merelbeke