Exploring novel drug delivery strategies in rheumatoid arthritis: nanomedicines and ultrasound triggered drug delivery.

Deprez, Joke
Faculteit Farmaceutische Wetenschappen
Vakgroep Geneesmiddelenleer
Master in Geneesmiddelenontwikkeling, Farmacie, UGent (June 2017) Latin-Mathematics, Sint Bavohumaniora Gent (June 2012)
Academische graad
Doctor in de farmaceutische wetenschappen
Taal proefschrift
Vertaling titel
Het exploreren van nieuwe afleveringstrategieën voor geneesmiddelen bij reumatoïde artritis: nanomedicijnen en ultrasound-gestuurde aflevering.
Prof. dr., Stefaan De Smedt, UGent-Geneesmiddelenleer - Prof. dr., Peggy Jacques, UGent-Faculteit Geneeskunde en Gezondheidswetenschappen - dr., Ine Lentacker, UGent-Geneesmiddelenleer
Prof. dr., Christophe Stove, UGent-Bioanalyse - Prof. dr., Aurélie Crabbé, UGent-Farmaceutische Analyse - Prof. Dr., Dirk Elewaut, UZ Gent - Prof. Dr., Guillaume Lajoinie, University Of Twente - Prof. Dr., Seyed Moghimi, Newcastle University - Prof. Dr., Roy van der Meel, Precision medicine–Department of biomedical engineering

Korte beschrijving

Today, anti-rheumatic therapy is mainly focused on suppressing the inflammation to prevent RA-associated cartilage and bone destruction. Therefore classic anti-RA therapy includes orally administered small molecules or parenterally administered biologics (i.e. protein-based products) that resolve inflammation. However, numerous preclinical studies have confirmed that the use of lipid nanocarriers, nano-sized drug encapsulating entities, such as liposomes can efficiently lead to the accumulation of drugs in the inflamed joints, thereby inducing favorable effects onto the disease progression. The added value of liposomes is believed to lie in a combination of factors. Namely, their ability (i) to selectively accumulate in the inflamed synovium; (ii) to enhance the pharmacokinetic profiles of drugs through controlled release and/or safeguard the drug from premature degradation, thereby also (iii) minimizing the side-effects that are associated with free circulating drugs. Despite the promising therapeutic outcomes observed with liposomes in the context of RA, the majority of liposomes is not able to reach the inflamed synovial tissue. The first aim of this thesis was therefore to investigate to what extent microbubble and ultrasound could further improve and steer liposome accumulation towards the inflamed joints. Especially in the case of mono-arthritis, i.e. arthritis where only one joint is affected, specific drug delivery to the diseased lesion is highly desired. Despite the enhanced accumulation of liposomes in inflammatory tissues, it is yet not clear if this can be solely attributed to the enhanced permeation an retention effect or whether immune cells are involved in their active transport, which was the second major aim of this thesis.


Donderdag 21 oktober 2021, 18:00
Faculteit Farmaceutische Wetenschappen - Auditorium A - Claudius Galenus, Ottergemsesteenweg 460, 9000 Gent
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