The equine sarcoid: from immunogenicity analysis and advances in diagnosis to unravelling cross-species BPV transmission

Promovendus/a
Gysens, lien
Faculteit
Faculteit Diergeneeskunde
Vakgroep
Vakgroep Heelkunde, Anesthesie en Orthopedie van de Grote Huisdieren
Curriculum
Lien Gysens was born in Lokeren on the 21st of February, 1995. After completing secondary school, majoring in science and mathematics, she started studying Veterinary Medicine at Ghent University in 2013. Throughout her university years, she participated in several extracurricular programmes. In 2014, she participated in a two-year university-wide Honours programme ‘Quetelet Colleges’. After completing her bachelor’s degree, she received the award ‘Top Student’ in 2016. The following two years, she participated in the Honours programme in Life Sciences: breaking frontiers, an interfaculty programme between the faculties of Veterinary Medicine, Pharmacy and Medicine and Health Sciences. In June 2019, she obtained the degree of Master of Veterinary Medicine (main subject Horse) with great distinction. In October of the same year, she joined the Department of Large Animal Surgery, Anaesthesia and Orthopaedics in Merelbeke as a PhD student, under the supervision of Prof. Dr. Ann Martens and Dr. Maarten Haspeslagh.
Academische graad
Doctor in de diergeneeskundige wetenschappen
Taal proefschrift
Engels
Promotor(en)
Prof. dr. Ann Martens, Faculty of Veterinary Medicine, UGent - Dr. Maarten Haspeslagh, Faculty of Veterinary Medicine, UGent

Korte beschrijving

Equine sarcoids are benign but locally aggressive fibroblastic skin tumours that affect equids worldwide. While early stages are considered harmless, tumours show a tendency to grow rapidly and often cause serious discomfort or even prevent the use of the horse. The high variety in clinical presentations goes hand in hand with a broad differential diagnosis. Therefore, it is important that clinicians can rely on an easy and rapid diagnostic tools to confirm clinical suspicion. In the meantime, many lines of evidence have established the causative role of bovine papillomavirus (BPV) types 1 and 2 in the multifactorial disease aetiology. Still, the exact pathogenesis is not fully understood and inoculation experiments with BPV in horses have not been successful in inducing actual equine sarcoids. In the horse, BPV infection is not cleared by the immune system, indicating that the virus is capable of immune evasion. Because no certain proof of infective virus (complete viral particles) has ever been found in horses, most authors believe BPV infection to be abortive in this species. This thesis compiles different research projects focusing on various facets of the disease (diagnostics, immunology, crossspecies transmission).

Praktisch

Datum
Dinsdag 5 december 2023, 17:30
Locatie
kliniekauditorium A, Salisburylaan 133, 9820 Merelbeke

If you would like to attend the reception, please register before November 24, by email to lien.gysens@ugent.be The defense will be followed by a reception in the Museum Morphology - Entrance 22, 1st floor.