How to select ‘the’ embryo for transfer: novel insights from advanced genetic analysis of bovine and equine embryos

De Coster, Tine
Faculteit Diergeneeskunde
Vakgroep Interne Geneeskunde, Voortplanting en Populatiegeneeskunde
Gezamenlijk doctoraat
KU Leuven
Tine De Coster was born on December 26, 1994 in Jette, Belgium. After graduating from secondary school at Koninklijk Atheneum Asse in 2012 (Latin Sciences), she started studying Veterinary Medicine at Ghent University. During her studies, she completed the extracurricular Honours Programme in Life Sciences. As a part of her master's thesis, she participated in an Erasmus+ program in Zambia In 2018, supported by a Burrough Wellcome award (Colorado State University). That same year, she graduated as a veterinarian (major in Research) with greatest distinction.
Academische graad
Doctor in de diergeneeskundige wetenschappen
Taal proefschrift
Prof. dr. Katrien Smits, Faculty of Veterinary Medicine, Ghent University - Prof. dr. Joris Robert Vermeesch, Faculty of Medicine, KU Leuven - Prof. dr. Ann Van Soom, Faculty of Veterinary Medicine, Ghent University

Korte beschrijving

Early embryo development involves a large number of sequentially coordinated and complex events, to which each parent contributes. The complexity of early embryonic development is reflected in cattle, horses and humans by the fact that most of early life seems to die rather prenatally than postnatally. Indeed, only about 30-44.5, 35, and 30% of in vivo-conceived bovine, equine and human gestations are respectively successful, resulting in liveborn offspring. Fertility can be increased by the application of assisted reproductive technologies (ART), allowing for production of more embryos that can be transferred to the uterus and additionally, be selected or ranked upfront according to their quality. Yet, with the help of ART, reproductive efficiency drops even further; an estimated rate of only 9.5, 13 and 12.5% of in vitro-fertilized bovine, equine and human oocytesresultsin liveborn offspring, respectively. Increased early embryonic mortality and pregnancy loss following ART is attributed to the exposure of the gametes and embryos to a suboptimal unnatural environment for a shorter or a longer time during the crucial and vulnerable period of gametogenesis and early embryonic development, which invariably imposes stresses upon them.


Donderdag 7 december 2023, 17:00
kliniekauditorium A, Salisburylaan 133, 9820 Merelbeke

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