Lezing 'The receptor for advanced glycation end-products (RAGE) is an important pattern recognition receptor (PRR) for inflammaging'

Voor wie
Medewerkers , Studenten
Wanneer
27-01-2022 van 16:00 tot 17:30
Waar
Livestream
Voertaal
Engels
Door wie
Faculty of Medicine and Health Sciences, Department of Internal Medicine and Pediatrics
Contact
Kim.DeKeyser@UGent.be
Website
https://www.ugent.be/ge/en/research/interdisciplinary-medicine-health-seminars.htm

Prof Boulanger will give a lecture on the role of the receptor for advanced glycation end-products in inflammaging.

This lecture is part of the IMHSeminars. Guest speaker: prof. Eric Boulanger

Advanced glycation end-products (AGEs) are molecules resulting from the non enzymatic interaction between proteins and sugars and are involved in processes such as diabetes or aging. Their main receptor, the receptor for AGEs (RAGE), is a pattern recognition receptor which binds with numerous ligands and promotes inflammatory responses, which have a central role in ageing in the context of inflammageing. Our work is focused on the role of dietary AGEs on aging and on the effects of RAGE modulation on vascular and renal aging in mice. We demonstrated that dietary AGEs accelerated MRI pulse wave velocity and reduced aortic ring relaxation in a RAGE dependent manner. Our results showed that while dietary AGEs had little effect on renal ageing, RAGE deletion largely reduced age-associated renal glomerulosclerosis, amyloidosis and inflammation.

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