Lezing 'Nucleic Acids Sensing by Innate Immune Receptors'

Voor wie
Alumni , Bedrijven , Medewerkers , Studenten
25-11-2022 van 11:30 tot 12:30
UGent-VIB-onderzoeksgebouw, Technologiepark 71, 9052 Zwijnaarde
Door wie
VIB-UGent Center for Inflammation Research

Jan Rehwinkel (MRC Weatherall Institute of Molecular Medicine, University of Oxford) will share their latest work on cytosolic nucleic acid sensors.

The innate immune response is critical for host defence against viruses. Cell-intrinsic mechanisms detect virus presence and restrict virus replication. Nucleic acids are often a molecular signature of infection and are recognised by receptors including Toll-like receptors, RIG-I-like receptors and cytosolic DNA sensors. These receptors signal for the induction of innate response genes such as those encoding type I interferons. These then induce the expression of restriction factors, host proteins that limit virus replication. Our work focuses on cytosolic nucleic acid sensors, in particular RIG-I, MDA5 and cGAS. We use in vitro and in vivo models of virus infections and are interested in rare genetic diseases linked to chronic anti-viral innate immune responses. In this presentation, I will discuss our recent work on MDA5, cGAS and other nucleic acid sensors.

Registration for this seminar is not required. To attend online, visit the website.