Eik Hoffmann (Pasteur Institute Lille, Center for Infection and Immunity of Lille (CIIL), Lille, France) is our guest speaker. Mycobacterium tuberculosis (Mtb), the pathogen causing human tuberculosis, has evolved multiple strategies to successfully prevent clearance by immune cells and to establish dissemination and long-term survival in the host. The modulation of host immunity to maximize pathogen elimination while minimizing inflammation-mediated tissue damage may provide another tool to fight drug-resistant Mtb strains. Our results provide evidence how rewiring of the TCA cycle confines the host response to Mtb via the IRG1/itaconate axis to restrict replication and dissemination of this pathogen.

Registration for this talk is not required. Online attending is possible.