EVENET seminar 21/11/17

21-11-2017 van 14:00 tot 15:00
Universiteit Gent, K.L. Ledeganckstraat 35, 9000 Gent (lecture room 11 th floor)
Door wie
Prof. dr. L.. Lens
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EVENET SEMINAR Dual transcriptomics of birds with malaria Elin Videvall Lund University

Malaria parasites engage in an endless evolutionary battle with the vertebrate immune

system. The way hosts control and suppress malaria infections on a molecular level, both during

acute and subsequent phases of infection, remains poorly understood. We experimentally

infected Eurasian siskins (Carduel/s spinus) with avian malaria parasites (Plasmodium spp.), and

used high-throughput dual RNA-sequencing to measure the avian transcriptome in blood

collected before infection, during peak infection, and when infection was decreasing.

Furthermore, we assembled the transcriptome of the malaria parasite de nova, and evaluated

the expression of parasite genes during the course of the infection. By analysing genome-wide

expression in the blood using RNA-sequencing, we gained a much more complete view of, not

only the host's molecular response to malaria, but also the counter strategies simultaneously

employed by the parasite.