In sacco-in vitro rumen bypass

Assessment of rumen bypass and post-ruminal digestion (in sacco -in vitro)

Key highlights

  • Exposure of test products to rumen microbial inoculum in mini nylon bags
  • Resistance assessment of test products against microbial degradation
  • Post-ruminal digestion simulation using mini nylon bag residues after rumen exposure
  • Optimised for testing encapsulated products relying on fat- or protein-based coatings
  • Customizable and comprehensive analysis to meet diverse research requirements

Examples of possible research questions

  • Rumen bypass testing: evaluate how well (processed) feedstuffs or encapsulated/coated test products withstand breakdown by rumen microbes.
  • Post-ruminal release: study the release and bioavailability of rumen bypass products after they have passed through the rumen environment.

Research endpoints

Rumen microbial activity analysis

  • Total gas production and gas composition
  • Short-chain fatty acid production
  • Ammonium or lactate accumulation
  • Long-chain fatty acids including biohydrogenation intermediates
  • pH of rumen liquid

    Analysis of nylon bag residues, e.g.

    • micro-Kjeldahl analysis
    • amino acids
    • fatty acids, …
    • Analysis of products released from the nylon bags in the incubation medium (after rumen or post-ruminal simulation)
    • Delivery of the nylon bag residue or incubation medium for further analysis by customer

    Customized project-specific solutions

    We offer tailored experimental setup & analyses and are flexible to meet your unique research needs