Seizure onset zone localization from ictal high-density EEG

For patients with refractory epilepsy, surgery is the most efficient treatment option. To make this possible, an accurate delineation of the epileptic focus is necessary. In this research, we investigate how to localize this seizure onset zone based on high-density EEG recordings during a seizure. Therefore, we focus on the fact that there is increasing evidence that epilepsy is a network disease. During a seizure, several brain regions become simultaneously active in an epileptic network and it is hard to discern the main driver of this network. First, we identify the brain activity during a seizure using ESI. Next, we discriminate the epileptic network and try to find it’s driver using functional connectivity analysis.

Researcher: Willeke Staljanssens