Molecular MRI in early radiation injury detection

With conventional magnetic resonance imaging, radiation injury in healthy tissue is only visible at a late stage. Its sensitivity is too small to allow molecular imaging. However, labeling of superparamagnetic particles, e.g., micron-sized particles of iron oxide (MPIOs) with highly specific antibodies, can circumvent this issue. Using this molecular MRI technique, we investigate the early signs of radiation injury, focusing on inflammation-related intravascular molecules.