Comparison of Ga68-PSMA and F18-PSMA in clinical and preclinical studies.

Prostate-specific membrane antigen (PSMA) is highly overexpressed in prostate cancer. Many PSMA analog radiotracers for PET/CT prostate cancer staging have been developed, such as 68Ga-PSMA-11. This radiotracer has achieved good results in multiple clinical trials, but because of the superior imaging characteristics of 18F-fluoride, 18F-PSMA-11 was developed.  The aim of this study is to compare the prostate‐specific membrane antigen (PSMA)‐targeting characteristics of PSMA‐11, radiolabeled based on chelation of 18F‐AlF, to those of 68Ga‐PSMA‐11 to image PSMA‐expressing xenografts.