Scientific articles and chapters in books

All publications from the last years, resulting from research work involving one or more staff members of the Laboratory of Medical Biochemistry and Clinical Analysis.

For a complete overview, please visit the web page of the Ghent University Library database of academic publications (in Dutch).

Requests for reprints: Jan Van Bocxlaer

2012

L. De Bock, K. Boussery, P. Colin, J. De Smet, H. T’jollyn, J. Van Bocxlaer.
Development and validation of a fast and sensitive UPLC-MS/MS method for the simultaneous quantification of six probe metabolites for the in vitro determination of cytochrome P450 activity. Talanta, 89 (2012) 209-216.

L. De Bock, P. Colin, K. Boussery, J. Van Bocxlaer. Development and validation of an enzyme-linked immunosorbent assay for the quantification of cytochrome 3A4 in human liver microsomes. Talanta, 99 (2012) 357-362.

P. Colin, L. De Bock, H. T’jollyn, K. Boussery, J. Van Bocxlaer. Development and qualification of a fast and uniform approach to quantify β-lactam antibiotics in human plasma by solid phase extraction-liquid chromatography-electrospray-tandem mass spectrometry. Talanta, doi: 10.1016/j.talanta.2012.10.046.

L. De Bock, K. Boussery, M. Van Winckel, P. De Paepe, X. Rogiers, X. Stephenne, E. Sokal, J. Van Bocxlaer. In vitro cytochrome P450 activity decreases in children with high Paediatric End-Stage Liver Disease scores. Drug Metabolism and Disposition, doi:10.1124/dmd.112.048504.

L. De Bock and A. Osselaere, V. Eeckhoudt, P. De Backer, J. Van Bocxlaer, K. Boussery, S. Croubels. Hepatic and intestinal CYP3A expression and activity in broilers. Accepted in Journal of Veterinary Pharmacology and Therapeutics.

A. Osselaere, S.J. Li, L. De Bock, M. Devreese, J. Goossens,V. Vandenbroucke, J. Van Bocxlaer, K. Boussery, F. Pasmans, A. Martel, P. De Backer, S. Croubels. Toxic Effects of Dietary Exposure To T-2 Toxin On Intestinal And Hepatic Biotransformation Enzymes and Drug Transporter Systems In Broilers. Accepted in Food and Chemical Toxicology.

K. Cattoor, M. Dresel, L. De Bock, T. Hofmann, K. Boussery, D. Tensy, J. Van Bocxlaer_,J-P. Remon_,D. Deforce, A. Heyerick_,D. De Keukeleire. Study of the metabolism of hop-derived bitter acids. Submitted to Journal of Agricultural and Food Chemistry.

L. De Bock, K. Boussery, P. Colin, J. Van Bocxlaer. Quantification of cytochrome 2E1 in human liver microsomes using a fully validated indirect ELISA. Submitted to Bioanalysis.

L. De Bock and J. Goossens, A. Osselaere, E. Verbrugghe, M. Devreese, K. Boussery, J. Van Bocxlaer, P. De Backer, S. Croubels. The mycotoxin T-2 inhibits hepatic cytochrome P4503A activity in pigs. Submitted to Food and Chemical Toxicology.

Lieselotte De Smet, Pieter Colin, Wim Ceelen, Marc Bracke, Jan Van Bocxlaer, Jean Paul Remon and Chris Vervaet. Development of a nanocrystalline paclitaxel formulation for HIPEC treatment. Pharmaceutical Research 29(9). p 2398-2406 (2012)

Markus Tschopp, Johannes Stary, Beatrice E Frueh, Wolfgang Thormann, Julie De Smet, Jan Van Bocxlaer and Christoph Tappeiner. Impact of corneal cross-linking on drug penetration in an ex vivo porcine eye model. Cornea 31(3), p 222-226 (2012)

Julie De smet, Pieter Colin, Peter De Paepe, Johannes Ruige, Hélène Batens, Yves Van Nieuwenhove, Dirk Vogelaers, Stijn Blot, Jan Van Bocxlaer and Lucas Van Bortel, et al. Oral bioavailability of moxofloxacin after Roux-en Y gastric bypass surgery. Journal of antimicrobial chemotherapy 67(1), p.226-229 (2012)

2011

L. De Bock, S. Vande Casteele, S. Mulliez, K. Boussery, J. Van Bocxlaer. In vitro cytochrome P450 activity: Development and validation of a sensitive high performance liquid chromatography-tandem mass spectrometry method for the quantification of six probe metabolites after derivatization with pyridine-3-sulfonyl chloride. Journal of Chromatography A, 1218 (2011) 793-801 .

K. Cattoor; J.P. Remon; K. Boussery; J. Van Bocxlaer, M. Bracke, D. De Keukeleire, D Deforce, and A. Heyerick. Bioavailability of hop-derived iso-alpha-acids and reduced derivatives. Food & Function. 2, issue 7, 412-422 (2011).

M.J. Coppens; D.J. Eleveld; J.H. Proost; L.A.M. Marks, J.F.P. Van Bocxlaer, H. Vereecke, A.R. Absalom, and M.M.R.F. Struys. An Evaluation of Using Population Pharmacokinetic Models to Estimate Pharmacodynamic Parameters for Propofol and Bispectral Index in Children. Anesthesiology. 115:1, 83-93 (2011). IF₂₀₁₀: 5,486. Rank: 1 op 26.

H. T'jollyn; K. Boussery; R.J. Mortishire-Smith; K. Coe, B. De Boeck, J.F. Van Bocxlaer, and G. Mannens. Evaluation of Three State-of-the-Art Metabolite Prediction Software Packages (Meteor, MetaSite, and StarDrop) through Independent and Synergistic Use. Drug Metabolism and Disposition. 39:11, 2066-2075 (2011). IF₂₀₁₀: 3,716. Rank: 52 op 252

K. Boussery, J. De Smet, P. De Cock, S. Vande Velde, E. Mehuys, P. De Paepe, J.P. Remon, J.F.P. Van Bocxlaer, and M. Van Winckel. Pharmacokinetics of two formulations of omeprazole administered through a gastrostomy tube in patients with severe neurodevelopmental problems. Brit. J. Clin. Pharmacol. 72:6, 990-996 (2011). IF₂₀₁₀: 3,063. Rank: 74 op 252.

Mieke Callier, Kathleen Deiteren, Jan van Bocxlaer and Kathleen Croes. Human salivary cortisol, part I: development and full validation of an LC-MS/MS based method. Acta Clinica Belgica 66(2) p. 163-163

2010

J. De Smet, K. Boussery, P. De Cock, P. De Paepe, J.P. Remon, M. Van Winckel J. Van Bocxlaer. A bio-analytical HILIC-MS/MS method for the simultaneous quantification of omeprazole and lansoprazole in human plasma in support of a pharmacokinetic omeprazole study in children. Journal of Separation Science 2010, 33, 939-947 (IF 2009: 2,551).
K. Boussery, J. De Smet, P. De Cock, S. Vande Velde, E. Mehuys, P. De Paepe, J.P. Remon, J.F.P. Van Bocxlaer, M. Van Winckel. Pharmacokinetics of the proton pump inhibitor omeprazole administered through a gastrostomy tube in patients with cerebral palsy and mental retardation. British Journal of Pharmacology (IF 2009: 5,204)
M. B. Munk, K. Huvaere, J. Van Bocxlaer and L. H. Skibsted. Mechanism of light-induced oxidation of nitrosylmyoglobin. Food Chem. 121, 472-479 (2010). IF₂₀₁₀: 3,458. Rank: 4 op 70, 5 op 128, 13 op 70.
B. Baert, J. Boonen, C. Burvenich, N. Roche, F. Stillaert, P. Blondeel, J. Van Bocxlaer and B. De Spiegeleer. A new discriminative criterion for the development of Franz diffusion tests for transdermal pharmaceuticals. J. Pharm. Pharm. Sci. 13/2, 218-230 (2010). IF₂₀₁₀: 1,914. Rank: 145 op 252.
S. Cooreman, C. Deprez, F. Martens, J. Van Bocxlaer, and Katheen Croes. A comprehensive LC-MS based quantitative analysis of fentanyl-like drugs in plasma and urine. J. Sep. Sci. 33, 2654-2662 (2010). IF₂₀₁₀: 2,631. Rank: 23 op 73.
S. Van Dorpe, A. Adriaens, I. Polis, K. Peremans, J. Van Bocxlaer, and B. De Spiegeleer. Analytical characterization and comparison of the blood-brain barrier permeability of eight opioid peptides. Peptides. 31/7, 1390-1399 (2010). IF₂₀₁₀: 2,654. Rank: 151 op 286, 99 op 252.
D. Usmanov, U. Khasanov, A. Pantsirev, and J. Van Bocxlaer. Analysis of omnoponum by surface-ionization mass spectrometry and liquid chromatography tandem mas spectrometry methods. J. Pharm. Biomed. Analysis. 53, 1058-1062 (2010). IF₂₀₁₀: 2,733. Rank: 20 op 73, 91 op 252.
S. Cooreman, C. Deprez, F. Martens, J. Van Bocxlaer, and K. Croes. A comprehensive LC-MS-based quantitative analysis of fentanyl-like drugs in plasma and urine. J. Sep. Sci. 33, 2654-2662 (2010). IF₂₀₁₀: 2,631. Rank: 145 op 252.

2009

V. Polizzi, B. Delmulle, A. Moretti, A. Picco, Y. Rosseel, R. t’Kindt, A. Adams, J. Van Bocxlaer, N. De Kimpe, C. Van Peteghem and S. De Saeger. Fungi, mycotoxins and microbial volatile organic compounds in mouldy interiors from water-damaged buildings. J. Environ. Monitor. Accepted for publication (2009). IF₂₀₀₈: 1.989.
J. De Smet, K. Boussery, K. Colpaert, P. De Sutter, P. De Paepe, J. Decruyenaere and J. Van Bocxlaer. Pharmacokinetics of fluoroquinolones in critical care patients: a bio-analytical HPLC method for the simultaneous quantification of ofloxacin, ciprofloxacin and moxifloxacin in human plasma. J. Chromatogr. B. 877/10, 961-967 (2009). IF₂₀₀₈: 2.500
R. t’Kindt, K. Morreel, D. Deforce, W. Boerjan and J. Van Bocxlaer. Joint GC-MS and LC-MS platforms for comprehensive plant metabolomics: repeatability and sample pre-treatment. J. Chromatogr.B. Submitted for publication (2009). IF₂₀₀₈: 2.500
B. Baert, J. Boonen, C. Burvenich, N. Roche, P. Blondeel, J. Van Bocxlaer and B. De Spiegeleer. Influence of receptor fluid composition in Franz diffusion cell experiments. J. Pharm. Biomed. Anal. Submitted for publication (2009). IF₂₀₀₈: 2.629
M. Storme, R. t’Kindt and J. Van Bocxlaer. Improved analyte detectability of proteins and peptide lysates by means of multiple large-volume injection in LC-MS. J. Sep. Sci. Accepted for publication (2009). IF₂₀₀₈: 2.746
M.B. Munk, K. Huvaere, J. Van Bocxlaer and L.H. Skibsted. Light-induced oxidation of Nitrosylmyoglobin. Photoch. Photobio. Sci. Submitted for publication (2009). IF₂₀₀₈: 2.144

2008

M.L. Storme, R.S. t’Kindt, W. Goeteyn, K. Reyntjens and J.F. Van Bocxlaer. Quantitative determination of glycopyrolate in human plasma by liquid chromatography-electrospray ionization mass spectrometry: the use of a volatile ion-pairing agent during both liquid-liquid extraction and liquid chromatography. J. Chromatogr.B. 876 (1), 24-30 (2008).
t'Kindt Ruben, Storme Michael, Deforce Dieter and Van Bocxlaer Jan. Evaluation of hydrophilic interaction chromatography versus reversed-phase chromatography in a plant metabolomics perspective. J. Sep. Sci. 31, 1609-1614 (2008).
Christof Van Poucke, Christel Detavernier, Jan F. Van Bocxlaer, Rudi Vermeylen and Carlos Van Peteghem. Monitoring the benzene contents in soft drinks using headspace gas chromatography-mass spectrometry: a survey of the situation on the belgian market. J. Agr. Food Chem. 56, 4504-4510 (2008).
Ruben t'Kindt, Lieven De Veylder, Michael Storme, Dieter Deforce and Jan Van Bocxlaer. LC-MS metabolic profiling of Arabidopsis thaliana plant leaves and cell cultures: optimization of pre-LC-MS procedure parameters. J. Chromatogr. B. 871(1), 37-43 (2008).

2007

Michel M.R.F. Struys, M.D., Ph.D., Marc J. Coppens, M.D., Nikolaas De Neve, M.D., Eric P. Mortier, M.D., D.Sc., Anthony G. Doufas, M.D., Ph.D., Jan F.P. Van Bocxlaer Pha., Ph.D., and Steven L. Shafer, M.D. Influence of administration rate on propofol plasma-effect site equilibration. Anesthesiology, 107, 386-396 (2007).
Ruben t'Kindt, Goedele Alaerts, Yvan Vander Heyden, Dieter Deforce and Jan Van Bocxlaer. Broad-spectrum separations in metabolomics using enhanced polar LC stationary phases: A dedicated evaluation using plant metabolites. J. Sep. Sci. 30, 2002-2011 (2007).

2006

F.C.W. Van Nieuwerburgh, S.R.F. Vande Casteele, L. Maes, A. Goossens, D. Inzé, J.F. Van Bocxlaer, and D.L.D. Deforce. Quantitation of artemisinin and its biosynthetic precursors in Artemisia annua L. by HPLC-Electrospray Q-TOF MS/MS. J. Chromatogr. A. 1118 (2), 180-187 (2006).

S. Gosav, M. Praisler, J. Van Bocxlaer, A.P. De Leenheer, and D.L. Massart. Class identity assignment for amphetamines using neural networks and GC-FTIR data. Spectrochimica Acta Part A. 64 (5), 1110-1117 (2006).

M.L. Storme, F.H. Jansen, W. Goeteyn, and J.F. Van Bocxlaer. Simultaneous quantitative analysis of the antimalarials pyrimethamine and sulfamethoxypyrazine in plasma samples using liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 20, 2947-2953 (2006).

K. Huvaere, M.L. Andersen, M. Storme, J. Van Bocxlaer, L.H. Skibsted, and D. De Keukeleire. Flavin-induced photodecomposition of sulfur-containing amino acids is decisive in the formation of beer lightstruck flavor. Photochem. Photobiol. Sci. 5, 961-969 (2006).

E.A. De Letter, W.E. Lambert, M.-P. L.A. Bouche, J.A.C.M. Cordonnier, J.F. Van Bocxlaer, and M.H. Piette. Postmortem distribution of 3,4-methylenedioxy-N,N-dimethyl-amphetamine (MDDM or MDDA) in a fatal MDMA overdose. Int. J. Legal Med. 121/4, 303-307 (2006).

2005

J.F. Van Bocxlaer, S.R. Vande Casteele, C.J. Van Poucke and C.H. Van Peteghem. Confirmation of the identity of residues using Q-TOF mass spectrometry. Analytica Chimica Acta. 529, 65-73 (2005).
A.V. Willems, D.L. Deforce, C.H. Van Peteghem, and J.F. Van Bocxlaer. Development of a quality control method for the characterization of oligonucleotides by capillary zone electrophoresis-electrospray ionization quadrupole time-of-flight mass spectrometry. Electrophoresis 26 (7-8), 1412-1423 (2005).
A.V. Willems, D.L. Deforce, C.H. Van Peteghem, and J.F. Van Bocxlaer. Analysis of nucleic acid constituents by on-line capillary electrophoresis-mass spectrometry. Electrophoresis 26 (7-8), 1221-1253 (2005).
B.A. Sinnaeve, T.N. Decaestecker, P.G. Risha, J.-P. Remon, C. Vervaet, and J.F. Van Bocxlaer. Liquid chromatographic mass spectrometric assay for simultaneous pyrimethamine and sulfadoxine determination in human plasma samples. J. Chrom. A. 1076, 97-102 (2005).
M.L. Storme, B.A. Sinnaeve, and J.F. Van Bocxlaer. The use of tryptic marker peptides for the quantitative analysis of cystatin C. J. Sep. Sci. 28 (14), 1759-1763 (2005).
B.A. Sinnaeve, M.L. Storme, and J.F. Van Bocxlaer. Capillary liquid chromatography and tandem mass spectrometry for the quantification of enkephalins in cerebrospinal fluid. J. Sep. Sci. 28 (14), 1779-1784 (2005).
S.R. Vande Casteele, M.-P. L. Bouche, and J.F. Van Bocxlaer. LC-MS/MS in the elucidation of an isomer of the recreational drug methylenedioxy ethylamphetamine (MDEA): methylenedioxy dimethylamphetamine. J. Sep. Sci. 28 (14), 729-1734 (2005).
S. Caetano, T. Decaestecker, R. Put, M. Daszykowski, J. Van Bocxlaer, and Y. Vander Heyden. Exploring and modelling the responses of ESI and APCI ionization techniques based on molecular descriptors. Anal. Chim. Acta. 550 (1-2) 92-106 (2005).
J.F. Van Bocxlaer, Recent trends in analytical procedures in forensic toxicology. Ther. Drug. Monitor, In press (2005).
P.G. Risha, M.-P. Bouche, C. Vervaet, J. Van Bocxlaer, L. Van Bortel, and J.-P. Remon. Influence of in-vitro dissolution rate on the bioavailability of acetylsalicylic Acid Tablets. Eur. J. Clin. Pharmacol. Submitted (2004).

2004

M. Struys, M.-P. Bouche, G. Rolly, Y. Vandevivere, D. Dyzers, W. Goeteyn, L. Versichelen, J. Van Bocxlaer, and E. Mortier. Production of Compound A and carbon monoxide in circle systems: an in-vitro comparison of two carbon dioxide absorbents. Anesthesia. 59, 584-589 (2004).
E.A. Letter, M.-P. Bouche, J.F. Van Bocxlaer, W.E. Lambert, and M.H.A. Piette. Interpretation of a 3,4-methylenedioxymethamphetamine (MDMA) blood level: discussion by means of a distribution study in two fatalities. Forensic Sci. Int. 141, 85-90 (2004)
K. Clauwaert, T. Decaestecker, K. Mortier, W. Lambert, D. Deforce, C. Van Peteghem, and J. Van Bocxlaer. The determination of cocaine, benzoylecgonine and cocaethylene in small volume oral fluid samples by liquid chromatography-quadrupole time-of-flight mass spectrometry. J. Anal. Toxicol. 28, 655-659 (2004).
T.N. Decaestecker, W.E. Lambert, C.H. Van Peteghem, D. Deforce, and J.F. Van Bocxlaer. Optimization of a solid-phase extraction for a LC-MS/MS general unknown screening procedure by means of computational techniques. J. Chromatogr. A. 1056, 57-65 (2004).
B.A. Sinnaeve and J.F. Van Bocxlaer. Evaluation of nano-LC MS/MS in a column switching setup for the absolute quantification of peptides in the picomolar range. J. Chromatogr. A. 1058, 113-119 (2004).
T.N. Decaestecker, S.R. Vande Casteele, P.E. Wallemacq, C.H. Van Peteghem, D.L. Deforce and J.F. Van Bocxlaer. An IDA mediated LC-MS/MS screening procedure with semi-quantitative potential. Anal. Chem. 76(21), 6365-6373 (2004).
K. Huvaere, B. Sinnaeve, J. Van Bocxlaer, and D. De Keukeleire. Photooxidative degradation of beer bittering principles: product analysis with respect to light struck flavour formation. Photochem. Photobiol. Sci. 3, 854-858 (2004).
A.V. Willems, D.L. Deforce, W.E. Lambert, C.H. Van Peteghem, and J.F. Van Bocxlaer. Rapid characterization of oligonucleotides by capillary liquid chromatography - nano electrospray quadrupole time-of-flight mass spectrometry. J. Chromatogr. A. 1052, 93-101 (2004).

2003

T.N. Decaestecker, E.M. Coopman, C.H. Van Peteghem, and J.F. Van Bocxlaer. Suitability testing of commercial solid-phase extraction sorbents for sample clean-up in systematic toxicological analysis using liquid chromatography-(tandem) mass spectrometry. J. Chromatogra. B. 789 (1), 19-25 (2003).
K. Clauwaert, S. Vande Casteele, B. Sinnaeve, D. Deforce, W. Lambert, C. Van Peteghem, and J. Van Bocxlaer. Exact mass measurement of product ions for the structural confirmation and identification of unknown compounds using a quadrupole time-of-flight spectrometer: a simplified approach using combined tandem mass spectrometric functions. Rapid Commun. Mass Spectrom. 17(13), 1443-1448 (2003).
I. Claerhout, Ph. Kestelyn, J.-P. Remon, T. Decaestecker, J. Van Bocxlaer, and F. Meire. Corneal deposits after the topical use of ofloxacin in two children with vernal keratoconjunctivitis. Brit. J. Ophtalmol. 87(5), 646-648 (2003).
B.A. Sinnaeve, T.N. Decaestecker, I.J. Claerhout, P. Kestelyn, J.-P. Remon, and J.F. Van Bocxlaer. Confirmation of ofloxacin precipitation in corneal deposits by microbore liquid chromatography-quadrupole time-of-flight tandem mass spectrometry J. Chromatogr B. 785, 193-196 (2003).

2002

A.V. Willems, D.L. Deforce, E.G. Van den Eeckhout, W.E. Lambert, C.H. Van Peteghem, A.P. De Leenheer, and J.F. Van Bocxlaer. Analysis of benzoa]pyrene diol epoxide-DNA adducts by capillary zone electrophoresis ionization mass spectrometry in conjunction with sample stacking. Electrophoresis 23(24), 4092-4103 (2002)
K.A. Mortier, K.E. Maudens, W.E. Lambert, K.M. Clauwaert, J.F. Van Bocxlaer, D.L. Deforce, C.H. Van Peteghem, and A.P. De Leenheer. Simultaneous, quantitative determination of opiates, amphetamines,cocaine, and benzoylecgonine in oral fluid by liquid chromatography quadrupole-time of flight mass spectrometry. J. Chromatogr. B 799, 321-330 (2002)
M. Praisler, S. Gosav, J. Van Bocxlaer, A. De Leenheer, and D.L. Massart. Exploratory analysis for the identification of amphetamines using neural networks and GC-FTIR data, The Annals of the University "Dunãrea de Jos", Fascicle II, 2002, p. 83-96, ISSN 1221-4531.
M. Praisler, J. Van Bocxlaer, A. De Leenheer, and D.L. Massart. Automated recognition of ergogenic aids using soft independent modeling of class analogy (SIMCA). Turk. J. Chem. 26(1), 45-58 (2002).
M.-P. L.A. Bouche, L.M. Versichelen, M.M.R.F. Struys, J.F.P. Van Bocxlaer, A.P. De Leenheer, E.P. Mortier, and G. Rolly. No compound A formation with superiaR during minimal-flow sevoflurane anesthesia - A comparison with sofnolimeR. Anest. & Analg. 95, 1680-1685 (2002)
E.A. De Letter, K.M. Clauwaert, F. M. Belpaire, W.E. Lambert, J.F. Van Bocxlaer, and M.H.A. Piette. Post-mortem redistribution of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in the rabbit. Part two: Post-mortem infusion in trachea or stomach. Int. J. Legal Med. 116, 225-232 (2002).
E.A. De Letter, K.M. Clauwaert, F. M. Belpaire, W.E. Lambert, J.F. Van Bocxlaer, and M.H.A. Piette. Post-mortem redistribution of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in the rabbit. Part one: Experimental approach after in vivo intravenous infusion. Int. J. Legal Med. 116, 216-224 (2002).
M. Praisler, J. Van Bocxlaer, A. De Leenheer, and D.L. Massart. Chemometric detection of thermally degraded samples in the analysis of drugs of abuse with GC-FTIR spectroscopy. J. Chromatogr. A 962, 161-173 (2002).
E.A. De Letter, K.M. Clauwaert, W.E. Lambert, J.F. Van Bocxlaer, A. P. De Leenheer, and M.H.A. Piette. Distribution study of 3,4-methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine in a fatal overdose. J. Anal. Toxicol. 26, 113-118 (2002).
M.-P. L.A. Bouche, W.E. Lambert, J.F.P. Van Bocxlaer, M.H. Piette, and A.P. De Leenheer. Quantitative determination of n-propane, isobutane and n-butane by headspace GC-MS in intoxications by inhalation of lighter fluid. J. Anal. Toxicol. 26, 35-42 (2002).

2001

K.A. Mortier, K.M. Clauwaert, W.E. Lambert, J.F. Van Bocxlaer, E.G. Van den Eeckhout, C.H. Van Peteghem, and A.P. De Leenheer. Pitfalls associated with liquid chromatography/electrospray tandem mass spectrometry in quantitative bioanalysis of drugs of abuse in saliva. Letter. Rapid commun. Mass Spectrom. 15, 1773-1775 (2001).
M. Praisler, I. Dirinck, J. Van Bocxlaer, A. De Leenheer, and D.L. Massart. Computer-aided screening for hallucinogenic and stimulant amphetamines with gas chromatography-Fourier transform infrared spectroscopy (GC-FTIR). J. Anal. Toxicol. 25, 45-56 (2001).
M.-P. Bouche, J.F. Van Bocxlaer, G. Rolly, L.F. Versichelen, M. M. Struys, E. Mortier, and A.P. De Leenheer. Quantitative determination of vapor phase compound A in Sevoflurane anesthesia using gas chromatography - mass spectrometry. Clin. Chem. 47:2, 281-291 (2001).

R. Dams, T. Benijts, W. Lambert, J. Van Bocxlaer, D. Van Varenbergh, and A. De Leenheer. A fatal case of serotonin syndrome after combined moclobemide/citalopram intoxication. J. Anal. Toxicol. 25, 147-151 (2001).
L. Versichelen, M.-P. Bouche, M. Struys, J. Van Bocxlaer, E. Mortier, A. De Leenheer, and G. Rolly. KOH-free CO2 absorbent is not associated with less compound A production than with classical soda lime during in-vitro closed circuit sevoflurane administration. Br. J. Anaesthes. 86, 345-348 (2001).
L.M. Versichelen, M.-P. L.A. Bouche, G. Rolly, J.F.P. Van Bocxlaer, M.M.R.F. Struys, E.P. Mortier, and A.P. De Leenheer. Only carbondioxide absorbents free of both NaOH and KOH do not generate compound A during in vitro closed-system sevoflurane: evaluation of five absorbents. Anaesthesiology 95, 750-755 (2001).
K.M. Clauwaert, J.F. Van Bocxlaer, and A.P. De Leenheer. Stability study of the designer drugs 'MDA, MDMA and MDEA" in water, serum, whole blood and urine under various storage temperatures. Forensic Sci. Int. 124:1 36-42 (2001).
T. Decaestecker, E. De Letter, K. Clauwaert, M.P. Bouche, W. Lambert, J. Van Bocxlaer, M. Piette, E. Van den Eeckhout, C. Van Peteghem, and A. De Leenheer. Fatal 4-MTA intoxication. Development of a liquid chromatographic - tandem mass spectrometric assay for multiple matrices. J. Anal. Toxicol. 25, 705-710 (2001).
M. Praisler, J. Van Bocxlaer, A. De Leenheer, and D.L. Massart. Multivariate determination of the length of the side chain of illicit amphetamine analogues with GC-FTIR spectra. The Annals of the University "Dunarea de Jos", Fascicle II, XVIII 2000, 93-99 (2001). ISSN 1221-4531.

2000

K. Arys, J. Van Bocxlaer, E. Meyer, K. Clauwaert, W. Lambert, M. Piette, C. Van Peteghem, and A. De Leenheer. Quantitative Determination of Paraquat by HPLC-DAD following Chemical Reduction with Sodium Borohydride in a fatal intoxication. J. Anal. Toxicol. 24, 116-121 (2000).

M. Praisler, I. Dirinck, J. Van Bocxlaer, A. De Leenheer, and D.L. Massart. Exploratory analysis for the automated identification of amphetamines from vapour-phase FTIR spectra. Anal. Chim. Acta. 404,303 - 317 (2000).
K.M. Clauwaert, J.F. Van Bocxlaer, W.E. Lambert, and A.P. De Leenheer. Segmental analysis for cocaine and metabolites by HPLC in hair. Forensic. Sci. Int. 110, 157-166 (2000).
J.F. Van Bocxlaer, K.M. Clauwaert, W.E. Lambert, E.M. Van den Eeckhout, D.L. Deforce, A.P. De Leenheer. Liquid Chromatography - Mass Spectrometry in Forensic Toxicology. Mass Spectrom. Rev. 19, 165-214 (2000) (on invitation).
T.N. Decaestecker, K.M. Clauwaert, J.F. Van Bocxlaer, W.E. Lambert, E.G. Van den Eeckhout, C.M. Van Peteghem, and A.P. De Leenheer. Evaluation of automated MS to MS/MS function switching for comprehensive drug profiling analysis using a quadrupole Time-of-flight mass spectrometer. Rapid Commun. Mass Spectrom. 14, 1787-1792 (2000).
E.A. De Letter, P. De Paepe, K.M. Clauwaert, F.M. Belpaire, W.E. Lambert, J.F. Van Bocxlaer, M.H.A. Piette. Is vitreous humour useful for the interpretation of 3,4-methylenedioxymethamphetamine (MDMA) blood levels ? Experimental approach with rabbits. Int. J. Legal Med. 114, 29-35 (2000).
M. Praisler, I. Dirinck, J. Van Bocxlaer, A. De Leenheer, and D.L Massart. Pattern recognition techniques screening for drugs of abuse with gas chromatography - Fourier transform infrared spectroscopy. Talanta 53, 177-193 (2000).
M. Praisler, I. Dirinck, J. Van Bocxlaer, A. De Leenheer, and D.L Massart. Identification of novel illicit amphetamines from vapour-phase FTIR-spectra. A chemometrical solution. Talanta 53, 155-170 (2000).
L. Versichelen, G. Rolly, M.-P. Bouche, J. Van Bocxlaer, M. Struys, C. Van Der Herten, A. De Leenheer, and E. Mortier. In-vitro Compound A formation in a Computer-controlled Closed-circuit Anaesthesia Apparatus - comparison with a classical valve circuit. Anesthesiolgy 93(4), 1064-1068 (2000).
K.M. Clauwaert, J.F. Van Bocxlaer, E.A. De Letter, S. Van Calenbergh, W.E. Lambert, and A.P. De Leenheer. Determination of the designer drugs "MDMA, MDEA and MDA" with HPLC and fluorescence detection in whole blood, serum, vitreous humour and urine. Clin. Chem. 46/12, 1968-1977 (2000).
M. Praisler, J. Van Bocxlaer, A. De Leenheer, and D.L. Massart. Multivariate determination of the length of the side chain of illicit amphetamine analogues with GC-FTIR spectra. The Annals of the University "Dunãrea de Jos", Fascicle II, XVIII 2000, ISSN 1221-4531, p. 93-99.

1999

K.M. Clauwaert, J.F. Van Bocxlaer, H.J. Major, J.A. Claereboudt, W.E. Lambert, E.M. Van den Eeckhout, C.H. Van Peteghem, and A.P. De Leenheer. Investigation of the quantitative properties of the Q-TOF mass spectrometer with electrospray ionisation using 3,4-methylenedioxymethamphetamine. Rapid Commun. Mass Spectrom. 13, 1540-1545 (1999)

1998

K.M. Clauwaert, J.F. Van Bocxlaer, W.E. Lambert, E.M. Van den Eeckhout, F. Lemière, E.L. Esmans and A.P. De Leenheer. Narrow Bore HPLC in combination with Fluorescence and Electrospray Mass Spectrometric Detection for the Analysis of Cocaine and Metabolites in Human Hair. Anal. Chem. 70, 2336-2344 (1998).

I. Dirinck, E. Meyer, J. Van Bocxlaer, W. Lambert, and A. De Leenheer. Application of Gas Chromatography/Fourier Transform Infrared Spectrometry to the Analysis of Amphetamine Analogues. J. Chromatogr. A. 819, 155-159 (1998)

1997

J.F. Van Bocxlaer, W.E. Lambert, L.M. Thienpont, and A.P. De Leenheer. Quantitative determination of amphetamine and "a-phenylethylamine enantiomers in judicial samples using gas chromatography. J. Anal. Toxicol. 21, 5 - 11 (1997).

W.E. Lambert, J.F. Van Bocxlaer, and A.P. de Leenheer. Potential of High Performance Liquid Chromatography with Photodiode Array detection in forensic toxicology. J. Chromatogr. B 689, 45 - 53. (1997).
J.F. Van Bocxlaer, K.M. Clauwaert, W.E. Lambert, and A.P. De Leenheer. Quantitative colorimetric determination of urinary p-aminophenol using an automated analyser. Clin. Chem. 43, 627 - 634 (1997).
E. Meyer, J.F. Van Bocxlaer, I. Dirinck, W.E. Lambert, L. Thienpont, and A.P. De Leenheer. Tissue distribution of amphetamine isomers in a fatal overdose. J. Anal. Toxicol. 21, 236 - 239 (1997).

K.M. Clauwaert, J.F. Van Bocxlaer, W.E. Lambert, and A.P. De Leenheer. High Performance Liquid Chromatographic Determination of Cocaine, Benzoylecgonine and Cocaethylene in Whole Blood and Serum Samples with Diode Array Detection. J. Chromatogr. Sci. 35, 321 - 328 (1997).
W. Lambert, E. Meyer, J. Van Bocxlaer, and A.P. De Leenheer. Relevance of Toxicological Screening for Chloroquine in Non-malarious Areas. Letter. J. Anal. Toxicol. 21, 321 - 322 (1997).

1996

J. Van Bocxlaer, E. Meyer, K. Clauwaert, W. Lambert and A. De Leenheer. Analysis of Zopiclone (Imovane®) in Postmortem Specimens by GC-MS and HPLC with Diode-Array Detection. J. Anal. Toxicol. 20, 52 - 54 (1996).

Willy Lambert, Jan Van Bocxlaer, Michel Piette, and André De Leenheer. Authors reply to a Letter to the Editor "Trazodone and Dothiepin Poisoning". J. Anal. Toxicol. 20, 59 - 60 (1996).
E. Meyer, J.F. Van Bocxlaer, W.E. Lambert, L.M. Thienpont and A.P. De Leenheer. Identification of "a-phenylethylamine in judicial samples. J. Anal. Toxicol. 20, 116 - 120 (1996).

S.M. De Baere, W.E. Lambert, J.F. Van Bocxlaer and A.P. De Leenheer. Quantitative Gas Chromatographic Analysis of 3-cyano-3,3-diphenylpropionic acid, the Acidic Metabolite of Bezitramide (Burgodin®), in urine. J. Anal. Toxicol. 20, 159 - 164 (1996).
J. Van Bocxlaer, E. Meyer, K. Clauwaert, W. Lambert, M. Piette and A. De Leenheer. Authors reply to a letter to the Editor "Zopiclone poisoning". J. Anal. Toxicol. 20, 274 (1996).
K.M. Clauwaert, J.F. Van Bocxlaer, W.E. Lambert, and A.P. De Leenheer. Analysis of Cocaine, benzoylecgonine and cocaethylene in urine by HPLC with Diode Array Detection. Anal. Chem. 68, 3021 - 3028 (1996).

1995

E. Meyer, J.F. Van Bocxlaer, W.E. Lambert, M. Piette and A.P. De Leenheer. Determination of Chloral Hydrate and Metabolites in a Fatal Intoxication. J. Anal. Toxicol. 19, 124 - 126 (1995).
J.F. Van Bocxlaer, M. Claeys, H. Van den Heuvel and A.P. De Leenheer. Characterization of Acylcarnitines using Fast Atom Bombardment Spectrometry and Gas Chromatography Mass Spectrometry. J. Mass Spectrom. 30, 69 - 80 (1995).
E. Meyer, J. Van Bocxlaer, W. Lambert, L. Thienpont and A. De Leenheer. "_Phenylethylamine identified in judicial samples. Letter, Forensic Sci. Int. 76, 159 - 160 (1995).

Books (editorial activities, book chapters and proceedings)

K.M. Clauwaert, J.F. Van Bocxlaer, and A.P. De Leenheer. Encyclopedia of Mass Spectrometry. Ed. M.L. Gross and R. Caprioli. Vol. 4. Fundamentals of and Applications to Organic (and Organometallic) Compounds. Chapter 8: Determi-nation of Organic Compounds by Methods using Mass Spectrometry. Drugs in blood, urine. p. 907-917. Elsevier, Amsterdam. 2005. ISBN (vol. 4): 0-08-043846-6. ISBN (set): 0-08-043850-4.
A.V. Willems, D.L. Deforce, and J.F. Van Bocxlaer. Analysis of oligonucleotides using capillary zone electrophoresis and electrospray mass spectrometry. CE from small ions to macromolecules. Methods in Molecular Biology, Molecular Medicine, and Biotechnology series. Ed. P.D. Schmitt-Kopplin. Humana Press. Submitted 2005.
J.F. Van Bocxlaer and C.H. Van Peteghem. Confirmation of the identity of residues using Q-TOF Mass spectrometry. Proceedings of Euroresidue V, May 10-12, 2004. Noordwijkerhout, Nederland. Ed. L.A. Van Ginkel and A.A. Bergwerff. p. 39-44. ISBN 90-804 -925-2-3 (2004).
K. Mortier, W. Lambert, J. Van Bocxlaer, D. Deforce, C. Van Peteghem, A. De Leenheer. Simultaneous determination of eight drugs of abuse and codeine in saliva by liquid chromatography tandem mass spectrometry. Proceeding of the 40th TIAFT Meeting, Paris, France, August, 26-30, 2002
A.V. Willems, D.L. Deforce, W.E. Lambert, C.H. Van Peteghem, A.P. De Leenheer, and J.F. Van Bocxlaer. Fast analysis of oligonucleotides by capillary liquid chromatography-nano electrospray mass spectrometry combined with column switching. Proceedings of the 25th International symposium on capillary chromatography. May 13-17, 2002. Riva del Garda, Italy. Ed. P. Sandra. p. 11-18.
A.V. Willems, D.L. Deforce, E.G. Van den Eeckhout, W.E. Lambert, C.H. Van Peteghem, A.P. De Leenheer, and J.F. Van Bocxlaer. Analysis of benzo[a]pyrene diol epoxide-DNA adducts by capillary zone electrophoresis-nano-electrospray mass spectrometry. Proceedings of the 25th International symposium on capillary chromatography. May 13-17, 2002. Riva del Garda, Italy. Ed. P. Sandra. p. 1-10.
T. Decaestecker, E. De Letter, K. Clauwaert, M.P. Bouche, W. Lambert, J. Van Bocxlaer, M. Piette, E. Van den Eeckhout, C. Van Peteghem, and A. De Leenheer. Distribution profile study of 4-MTA based on a fatal intoxication. Proceedings of TIAFT 2001, 39th International Meeting, August, 26-30, 2001, Prague, Czech Republic. Ed. E. Nováková and V. Habrdová. Alfa, Varšavská 12, Praha 2 (2002).
T.N. Decaestecker, K.M. Clauwaert, W.E. Lambert, E.G. Van den Eeckhout, C.H. Van Peteghem, A.P. De Leenheer, and J.F. Van Bocxlaer. Data dependent MS to MS/MS switching using a Q-TOF in a forensic drug screening environment. Proceedings of the "Sesiunea de Comunicari Tehnico-Stiintifice" Braila, Romania. p. 1111-1115, Agir publishers, Bucharest, Romania (2002). ISBN 973-810-51-4.
M.P. Bouche, M. Praisler, J.F. Van Bocxlaer, and A.P. De Leenheer. A structured approach for screening the relevant factors in a PTV injection optimizing procedure. Proceedings of the "Sesiunea de Comunicari Tehnico-Stiintifice" Braila, Romania. p. 1117-1126, Agir publishers, Bucharest, Romania (2002). ISBN 973-810-51-4.
K. Arys, K. Clauwaert, B. De Craene, J. Claereboudt, W. Lambert, E. Van den eeckhout, C. Van Peteghem, and J. Van Bocxlaer. electrospray orthogonal-acceleration time-of-flight mass spectrometry for the analysis of bis-quaternary muscle relaxants in forensic toxicology. Advances in Mass Spectrometry, volume 15. Ed. E. Gelpi, p. 605-606. John Wiley & Sons, Chichester. (2001) ISBN 0-471-89153-3.
M.-P. Bouche, J. Van Bocxlaer, G. Rolly, L. Versichelen, M. Struys, e. Mortier, W. Lambert, and A. De Leenheer. Quantitative GC-MS of volatiles: Compound A determination in the vapour phase of sevoflurane based anesthesia systems. Advances in Mass Spectrometry, volume 15. Ed. E. Gelpi, p. 567-568. John Wiley & Sons, Chichester. (2001) ISBN 0-471-89153-3.
T. Decaestecker, K. Clauwaert, J. Van Bocxlaer, W. Lambert, E. Van den Eeckhout, c. Van Peteghem, and A. De Leenheer. evaluation of automated MS to MS/MS function switching for comprehensive drug profiling analysis using a quadrupole time-of-flight mass spectrometer. Advances in Mass Spectrometry, volume 15. Ed. E. Gelpi, p. 376-377. John Wiley & Sons, Chichester. (2001) ISBN 0-471-89153-3.
K. Clauwaert, J. Van Bocxlaer, A. Willems, K. Mortier, W. Lambert, E. Van den Eeckhout, C. Van Peteghem, and A. De Leenheer. Quantitation of amphetamine, methamphetamine MDA, MDMA, and MDEA in saliva with a QTOF LC-MS/MS system. Proceedings of TIAFT 2000, 38th international meeting, August 13-17, 2000, Helsinki, Finland. Ed. I. Rasanen, p. 417-422. Tallima Raamatutrükikoja OÜ (2001). ISBN 952-91-3405-3.
K. Clauwaert, J. Van Bocxlaer, T. Decaestecker, W. Lambert, E. Van den Eeckhout, C. Van Peteghem, and A. De Leenheer. Quantitation of cocaine, benzoylecgonine, and coca-ethylene in saliva with LC-MS/MS using small sample volumes. Proceedings of TIAFT 2000, 38th international meeting, August 13-17, 2000, Helsinki, Finland. Ed. I. Rasanen, p. 423-428. Tallima Raamatutrükikoja OÜ (2001). ISBN 952-91-3405-3.
R. Dams, T.H.P. Benijts, W.E. Lambert, J.F. Van Bocxlaer, D. Van Varenbergh, and A.P. De Leenheer. A fatal case of serotonin syndrome after combined moclobemide-citalopram intoxication Proceedings of TIAFT 2000, 38th international meeting, August 13-17, 2000, Helsinki, Finland. Ed. I. Rasanen, p. 194-198. Tallima Raamatutrükikoja OÜ (2001). ISBN 952-91-3405-3.
M.-P. Bouche, W. Lambert, J. Van Bocxlaer, M. Piette, and A. De Leenheer. Quantitative determination of n-propane, isobutane and n-nutane by headspace GC-MS in a fatal intoxication by inhalation of lighter fluid. Proceedings of TIAFT 2000, 38th international meeting, August 13-17, 2000, Helsinki, Finland. Ed. I. Rasanen, p. 199-204. Tallima Raamatutrükikoja OÜ (2001). ISBN 952-91-3405-3.
A.P. De Leenheer, W.E. Lambert, and J.F. Van Bocxlaer. The Encyclopedia of Separation Science. Toxicological Analysis: Liquid Chromatography. Academic Press, London (2000) p. 4388-4394.
K. Arys, J. Van Bocxlaer, E. Meyer, K. Clauwaert, W. Lambert, M. Piette, C. Van Peteghem, and A. De Leenheer. Quantitative Determination of Paraquat by HPLC-DAD following Chemical Reduction with Sodium Borohydride in a fatal intoxication. Proceedings of the 37th triennial Meeting of The International Association of Forensic Toxicologists, 5-9 september, 1999, Krakau, Polen. Eds. T. Lech, and J. Wójcikiewicz, p. 36-40. Institute of Forensic Research publishers, Krakow (2000). ISBN 1230-7483.
K. Arys, J. Van Bocxlaer, W. Lambert, C. Van Peteghem, and A. De Leenheer. Comparison of an enzymatic alcohol dehydrogenase assay and alcohol headspace GC-FID method using statistical analysis on real forensic blood and urine samples. Proceedings of the 37th triennial Meeting of The International Association of Forensic Toxicologists, 5-9 september, 1999, Krakau, Polen. Eds. T. Lech, and J. Wójcikiewicz, p. 18-23. Institute of Forensic Research publishers, Krakow (2000). ISBN 1230-7483.
Co-editor van "Modern Chromatographic Analysis of Vitamins" (Third Edition). Eds. A.P. De Leenheer, W.E. Lambert and J.F. Van Bocxlaer. Chromatographic Science Series. Marcel Dekker Inc., New York en Basel. 2000. ISBN 0-8247-0316-2.
I. Dirinck, M. Praisler, J. Van Bocxlaer, A. De Leenheer, and D.L Massart. Comparison between automated knowledge-based systems identifying and classifying amphetamine analogues using vapor-phase FTIR-spectra and mass spectra. Proceedings of the 37th triennial Meeting of The International Association of Forensic Toxicologists, 5-9 september, 1999, Krakau, Polen. Eds. T. Lech, and J. Wójcikiewicz, p. 62-69. Institute of Forensic Research publishers, Krakow (2000). ISBN 1230-7483.
W. Lambert, J. Van Bocxlaer, M. Piette and A. De Leenheer. A fatal case of trazodone and dothiepin poisoning: toxicogical findings. In: "Contributions to Forensic Toxicology": Proceedings of the 31st international meeting of the international association of forensic toxicologists, Leipzig '93. Ed. R.K. Mueller. Molinapress, Leipzig, 337-342 (1994). ISBN : 3-930364-00-X.
W.E. Lambert, E. Meyer, J.F. Van Bocxlaer, L. Thienpont and A.P. De Leenheer. Identification of a new amphetamine-like designer drug : alpha-phenylethylamine. Proceedings of the 33rd International Congress on Forensic (TIAFT) and 1st on Environmental Toxicology. Thessaloniki, Griekenland 27.08.95-31.08.95 Eds. A.V. Kovatsis and H. Tsoukali-Papadopoulou. 297-303 (1995).
S.M. De Baere, W.E. Lambert, J.F. Van Bocxlaer and A.P. De Leenheer. Quantitative gas chromatographic analysis of 3-cyano-3, 3-diphenylpropionic acid, the acidic metabolite of bezitramide (Burgodin®) in urine. Proceedings of the 33rd International Congress on Forensic Toxicology (TIAFT) and 1st on Environmental Toxicology. Thessaloniki, Griekenland 27.08.95-31.08.95. Eds. A.V. Kovatsis and H. Tsoukali-Papadopoulou. 396-401 (1995).

K.M. Clauwaert, J.F. Van Bocxlaer, W.E. Lambert and A.P. De Leenheer. Analysis of cocaine, benzoylecgonine and cocaethylene in whole blood and urine by HPLC with diode array detection. Proceedings of the 34th. Triennial Meeting of the International Association of Forensic Toxicologists, Interlaken, Zwitserland, 11.08.96-15.08.96. Eds. H. Sachs, W. Bernhard, and A. Jeger. Molinapress, Leipzig (1997). ISBN : 3-930865-03-3, p. 338-341.
J.F. Van Bocxlaer, K.M. Clauwaert, W.E. Lambert, M. Piette and A.P. De Leenheer. A fatality involving flunitrazepam : toxicological findings. Proceedings of the 34th. Triennial Meeting of the International Association of Forensic Toxicologists, Interlaken, Zwitserland, 11.08.96-15.08.96. Eds. H. Sachs, W. Bernhard, and A. Jeger. Molinapress, Leipzig (1997). ISBN : 3-930865-03-3, p. 205-207.
J.F. Van Bocxlaer, W.E. Lambert, and A.P. De Leenheer. Stereospecific determination of amphetamine and alpha-phenylethylamine enantiomers in judicial samples.Proceedings of the 34th. Triennial Meeting of the International Association of Forensic Toxicologists, Interlaken, Zwitserland, 11.08.96-15.08.96. Eds. H. Sachs, W. Bernhard, and A. Jeger. Molinapress, Leipzig (1997). ISBN : 3-930865-03-3, p. 389-393.