Department of Bioanalysis

oral presentations

2011

  • L. De Bock, S. Vande Casteele, S. Mulliez, K. Boussery, J. Van Bocxlaer. In vitro cytochrome P450 activity: Development and validation of a sensitive high performance liquid chromatography-tandem mass spectrometry method for the quantification of six probe metabolites after derivatization with pyridine-3-sulfonyl chloride. Annual BSMS Meeting on Mass spectrometry. April 29, 2011. Le Grand Hornu, Belgium.

2010

  • L. De Bock. Development and validation of an ELISA for the quantification of CYP3A4 in microsomes. 4rd annual Bio-Analysis Meeting of the department Bio-Analysis, Ghent University. December 20, 2010. Ghent, Belgium.

2009

  • L. De Bock. Changes in the metabolic capacity of the liver in children with severe hepatic dysfunction: in vitro assessment of major human cytochrome P450 enzyme activities. 3rd annual Bio-Analysis Meeting of the department Bio-Analysis, Ghent University. December 14, 2009. Ghent, Belgium.

  •  J. De Smet, K. Boussery, M. Van Winckel, P. De Cock, P. De Paepe, J.P. Remon, J. Van Bocxlaer. Pharmacokinetic study of omeprazole formulations in patients with cerebral palsy. Abstracts of the Scientific Meeting Clinical Pharmacology. March 7, 2009. Gent, Belgium.

  • R. t’Kindt, L. De Veylder, K. Morreel, D. Deforce and J. Van Bocxlaer.  LC-MS based metabolomics to unravel the endoreduplication impact on the metabolite level. Joint NVMS/BSMS Conference 2009, Kerkrade, The Netherlands. March 26-27, 2009.

  • J. De Smet, K. Boussery, M. Van Winckel, J. Van Bocxlaer. Pharmacokinetics of protonpumpinhibitors in children with cerebral palsy: a bio-analytical HILIC-MS/MS method for the simultaneous quantification of omeprazole and lansoprazole. 2-day International Conference on Mass spectrometry NVMS-BSMS. Kerkrade, The Netherlands. March 26-27, 2009.

  • J. De Smet, K. Boussery, M. Van Winckel, P. De Cock, P. De Paepe, J. Van Bocxlaer. Pharmacokinetics of omeprazole Multi-Unit Pellet System (Losec MUPS®) versus extemporaneous bicarbonate formulation in patients with cerebral palsy: a HILIC-MS/MS method for the quantification of omeprazole and lansoprazole. 11th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology (IATDMCT). October 4-8, 2009. Montréal, Québec, Canada.

2008

  • R. t’Kindt, L. De Veylder, D. Deforce and J. Van Bocxlaer.  Correlation between endoreduplication and metabolism in Arabidopsis thaliana: LC-MS based metabolomics approach. BSMS Annual meeting, February 15, 2008.

 

2007

  • J. Van Bocxlaer. “Drug analysis”. 5th European Summer School in Clinical Pharmacology and Therapeutics.   Gent, August 22-28, 2007 (on invitation)

 

2006

 

  • M.M.R.F. Struys, N. De Neve, E.P. Mortier, A.G. Doufas, J.F.P. Van Bocxlaer and S.L. Shafer.  The influence of administration rate on propofol plasma-effect site equilibration.  BVAR (Belgische Vereniging voor Anesthesie/Reanimatie) residents meeting. Annual meeting, Nov. 2006.  Affligem, Belgium.

2005

  • B. Sinnaeve, M. Storme, and J. Van Bocxlaer.  Capillary Liquid Chromatography and Tandem Mass Spectrometry for the Quantification of enkephalins in cerebrospinal fluid.  NVMS voorjaarsbijeenkomst 2005, April 29, 2005.  Haarlem, The Netherlands.

  • M. Storme, B. Sinnaeve, and J. Van Bocxlaer.  The use of markerpeptides for the absolute quantification of proteins.  NVMS voorjaarsbijeenkomst 2005.  April 29, 2005.  Haarlem, The Netherlands.

  • J.F. Van Bocxlaer.  Recent Trends in Analytical Procedures in Forensic Toxicology.  9th IATDMCT Conference April 23-28, 2005.  Louisville, KY, USA (on invitation).

  •  J.F. Van Bocxlaer. LC-MS in Toxicology from an EU users’ perspective.  35th SOFT meeting. October 17-21, 2005.  Nashville, TN, USA (on invitation).

2004

    • T.N. Decaestecker, W.E. Lambert, C.H. Van Peteghem, D. Deforce and J.F. Van Bocxlaer.  Optimization of a solid-phase extraction for a LC-MS/MS general unknown screening procedure by means of computational techniques.  8th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyses (HTC-8), 4-6 feb. 2004, Bruges, Belgium.


  • S. Vande Casteele and J. Van Bocxlaer.  Exact mass measurement of product ions for the structural confirmation and identification of unknown compounds using a quadrupole time-of-flight spectrometer: a simplified approach using combined tandem mass spectrometric functions.  NVMS and BSMS PhD platform meeting, 21 april 2004, Tilburg, The Netherlands.

  • J.F. Van Bocxlaer and C.H. Van Peteghem.  Confirmation of the identity of residues using Q-Tof mass spectrometry.  Euroresidue V Conference, May 10-12, 2004, Noordwijkerhout, Nederland.  Oral presentation on invitation.

  • J.F. Van Bocxlaer.  Analytical Techniques.  Clinical Pharmacology.  May 30, 2004.  Heymansinstituut, Ghent, Belgium (on invitation).

 

2003

  •  J. Van Bocxlaer and T. Decaestecker.  Information Dependent Acquisition: the way to go for LC-MS (/MS)  based general unknown screening.  21st Informal Meeting on Mass Spectrometry, May 11-15, 2003, Antwerp, Belgium (on invitation).

  • M.P. Bouche, E. De Letter, S. Vande Casteele, P. Van Rompaey, M. Piette, J. Van Bocxlaer.  Presence of N,N-dimethyl-3,4-methylenedioxyamphetamine (MDDM) in a fatal MDMA overdose.    41th TIAFT Meeting, 16-20 november 2003, Melbourne, Australia.

2002

  • E.A. De Letter, K.M. Clauwaert, F.M. Belpaire, W.E. Lambert, J.F. Van Bocxlaer, M.M.A. Piette.  Does post-mortem redistribution throw dust in the toxicologist’s eyes ?  Application to 3,4-methylene dioxymethamphetamine (MDMA, “ecstasy”) and experimental approach in rabbits.  Joint BLT-LTG meeting, March 8-9, 2002, Antwerp, Belgium.

  •  A.V. Willems, D.L. Deforce, E.G. Van den Eeckhout, W.E. Lambert, C.H. Van Peteghem, A.P. De Leenheer, and J.F. Van Bocxlaer.  Analysis of benzo[a]pyrene diol epoxide DNA adducts by capillary zone elctrophoresis-nano-electrospray mass spectrometry.  Proceedings of the 25th International Symposium on Capillary Chromatography, Palazzo dei Congressi, Riva del Garda, Italy, 14-17 mei 2002, Keynote Lecture 10.

  • T. Decaestecker, E. Coopman, C. Van Peteghem, and J. Van Bocxlaer.  Equivalence testing between commercial SPE sorbents for the sample clean-up in systematic toxicological analysing using LC-MS/MS.  40th TIAFT Meeting, August 26-30, 2002, Paris, France.


  • M.P. Bouche, M. Praisler, A. De Leenheer, and J. Van Bocxlaer.  A Structured Approach in  the Optimization of a Headspace and PTV-based injection for the Analysis of  Volatile Poisons.  40th TIAFT Meeting, August 26-30, 2002, Paris, France.

 

  • M.P. Bouche, P. Risha, T. Decaestecker, C. Vervaet, C. Van Peteghem, and J. Van Bocxlaer.  High throughput LC-MS/MS of Pyrimethamine and Sulfadoxine in limited volume plasma samples: combining selectivity from chromatography and fast ion separation by MS.  7th Annual BSMS Meeting on Mass Spectrometry, September 2, 2002, Gent, Belgium.

  • M.-P. L. Bouche, L.F. Versichelen, M.M. Struys, E. Mortier, and J.F. Van Bocxlaer.  GC-MS as a bioanalytical tool in the safety evaluation of sevoflurane inhalational anaesthesia.  FABIAN 2002 Meeting, Oktober 30, 2002, Weesp, The Netherlands (on invitation).

2001

  • K. Clauwaert, J. Van Bocxlaer, and A. De Leenheer.  Developments in confirmatory techniques for the analysis of oral fluids in toxicology.  “Oral Fluid in Toxicology”.  TIAFT Young Scientists Meeting. April 6-7, 2001, Ghent, Belgium.

  • K.A. Mortier, K.M. Clauwaert, W.E. Lambert, J.F. Van Bocxlaer, E.G. Van den Eeckhout, C.H. Van Peteghem, and A.P. De Leenheer.  Pitfalls associated with the use of a simple sample preparation in the analysis of saliva with LC-ESI-MS/MS.  “Oral Fluid in Toxicology”.  TIAFT Young Scientists Meeting.  April 6-7, 2001, Ghent, Belgium.

  • T.N. Decaestecker, K.M. Clauwaert, W.E. Lambert, E.G. Van den Eeckhout, C.H. Van Peteghem, A.P. De Leenheer, and J.F. Van Bocxlaer.  Data dependent MS to MS/MS switching using a Q-TOF in a forensic drug screening environment.  Sesiunea de Comunicari Tehnico-Scientifice.  Relansarea Economica  Õi sociala - Braila 2001, 22-24 Juni 2001, Braila, Roemenië.
  •  M.P. Bouche, M. Praisler, J.F. Van Bocxlaer, and A.P. De Leenheer.  A structured approach for screening the relevant factors in a PTV injection optimizing procedure.  Sesiunea de Comunicari Tehnico-Scientifice.  Relansarea Economica  Õi sociala - Braila 2001, 22-24 Juni 2001, Braila, Roemenië.

  •  K. Clauwaert, R. Kronstrand, and  J. Van Bocxlaer.  Amphetamines in hair.  Society of hair testing Workshop 2001.  “Interpretation of hair analysis” June 10-12, 2001, Bordeaux, France.  Mondelinge presentatie op uitnodiging.

  • K.A. Mortier, K.M. Clauwaert, W.E. Lambert, J.F. Van Bocxlaer, E.G. Van den Eeckhout, C.H. Van Peteghem, and A.P. De Leenheer.   Limitations of LC-ESI-MS/MS in the Analysis of Saliva after Protein precipitation.  HPLC 2001 conference, “The International Symposium on High Performance Liquid Phase Separations”.  June 17-22, 2001, Maastricht, The Netherlands.

  • T. Decaestecker, E. De Letter, K. Clauwaert, M.P. Bouche, W. Lambert, J. Van Bocxlaer, M. Piette, E. Van den Eeckhout, C. Van Peteghem, and A. De Leenheer.  Fatal 4-MTA intoxication: Development of a LC Tandem Mass Spectrometric Assay for Multiple Matrices.  39th Triennial meeting of the International Association of Forensic Toxicologists, August 26-30, 2001, Prague, Czech Republic.

  • M.P. Bouche, L. Versichelen, M. Struys, E. Mortier, G. Rolly, A. De Leenheer, and J. Van Bocxlaer.  Evaluation of CO2-absorbents for use in sevoflurane based closed circuit anesthesia through GC-MS determination of Compound A.  2ièmes Journées Internationales de Toxicologie Hospitalière Liège, 25-26 okt. 2001.

 

2000

  • M. Praisler, J. Van Bocxlaer, A. De Leenheer, and D.L. Massart.  Comparative analysis of pattern recognition techniques applied for the identification of narcotics.  3rd  MBCAC Conference, June 4 - 9, 2000.  Antalya, Turkey.

  •  M. Praisler, J. Van Bocxlaer, A. De Leenheer, and D.L. Massart.  Automated recognition of ergogenic aids using solft independent modeling of class analogy (SIMCA).  Abstracts of the 3rd MBCAC Conference, June, 4 - 9, 2000.  Antalya, Turkey.

  •  M.P. Bouche, W. Lambert, J. Van Bocxlaer, M. Piette, and A.P. De Leenheer.  Quantitative determination of n-propane, isobutane and n-butane by head space GC-MS in a fatal intoxication by inhalation of lighter fluid.  38th triennial Meeting of the International Association of Forensic Toxicologists, August 13 - 17, 2000.  Helsinki, Finland.

  • K.M. Clauwaert, J.F. Van Bocxlaer, T. Decaestecker, K. Mortier, W.E. Lambert, E.G. Van den Eeckhout, C. Van Peteghem, and A.P. De Leenheer.  Quantitation of cocaine, benzoylecgonine and cocaethylene in saliva with LC/MS/MS using small sample volumes.  38th triennial Meeting of The International Association of Forensic Toxicologists, August 13 - 17, Helsinki, Finland.

  • T.N. Decaestecker, K.M. Clauwaert, J.F. Van Bocxlaer, W.E. Lambert, E.M. Van den Eeckhout, C.M. Van Peteghem, and A.P. De Leenheer.  Evaluation of automated MS to MS/MS function switching for comprehensive drug profiling analysis using a Q-Tof mass spectrometer.  15th International Mass Spectrometry Conference, August 27 - Sept. 1, 2000, Barcelona, Spain.

  • R. Dams, T. Benijts, W. Lambert, J. Van Bocxlaer, D. Van Varenbergh, C. Van Peteghem, and A. De Leenheer.  A fatal case of serotonin syndrome after combined moclobemide/citalogram intoxication.  38th triennial Meeting of the International Association of Forensic Toxicologists, August 13 - 17, 2000.  Helsinki, Finland.

 

1999

  • J.F. Van Bocxlaer, K.M. Clauwaert, W.E. Lambert, and A.P. de Leenheer. Segmental Hair Analysis for the determination of cocaine Abuse. 51th Meeting of the American Academy of Forensic Sciences.  Orlando, Fl, 15 - 20 februari 1999.

  • K. Clauwaert, H. Major, J. Van Bocxlaer, J. Claereboudt, E. De Letter, W. Lambert, E. Van den Eeckhout, and C. Van Peteghem. Investigation of the quantitative properties of the Q-TOFTM mass spectrometer with electrospray ionization using XTC in various biological matrices of toxicological interest. 47th ASMS conference on Mass Spectro-metry and Allied Topics, 13-18 juni, 1999, Dallas, Texas, USA.

  •  K. Arys, J. Van Bocxlaer, E. Meyer, K. Clauwaert, W. Lambert, M. Piette, C. Van Peteghem, and A. De Leenheer. Quantitative Determination of  Paraquat by HPLC-DAD following Chemical Reduction with Sodium Borohydride in a fatal intoxication. 37th triennial Meeting of The International Association of Forensic Toxicologists, 5-9 september, 1999, Krakau.

  • J. Van Bocxlaer,  K. Clauwaert. Investigation of the quantitative potential of the Q-TOF for quantitative measurements of small organic molecules. Micromass product Seminar, 1999 European Pharmaceutical Tour Program, 20 mei 1999, Brussel (on invitation).

  • M. Praisler, I. Dirinck, J. Van Bocxlaer, A. De Leenheer, and D.L Massart. Structural investigation of amphetamines by modelling their molecular skeletons with GC-FTIR spectroscopy. Chemometrics V Conference, 29 aug. - 2 sept. 1999, Brno, Czech Republic.

  • M. Praisler, I. Dirinck, J. Van Bocxlaer, A. De Leenheer, and D.L Massart. Chemometrical detection of thermally degraded samples in the analysis of drugs of abuse with GC-FTIR spectroscopy. Chemometrics V Conference, 29 aug. - 2 sept. 1999, Brno, Czech Republic.

  • M. Praisler, I. Dirinck, J. Van Bocxlaer, A. De Leenheer, and D.L Massart. Expert system screening for drugs of abuse with gas chromatography - Fourier transform infrared spectroscopy. Colloquium Spectroscopicum Internationale XXXI. 5 - 10 sept. 1999, Ankara, Turkey.

  • M. Praisler, I. Dirinck, J. Van Bocxlaer, A. De Leenheer, and D.L Massart.  Identification of novel illicit amphetamines from vapour-phase FTIR-spectra. A chemometrical solution to the methodology. Colloquium Spectroscopicum Internationale XXXI. 5 - 10 sept. 1999, Ankara, Turkey.

  • J. Van Bocxlaer,  K. Clauwaert, H. Major, J. Claereboudt. What about the quantitative potential of the Q-TOF mass spectrometer: a study using XTC in various biological matrices. 2nd International Symposium on the enabling role of Mass Spectrometry. 5 - 6 oktober 1999, Manchester, Engeland. (on invitation).