Department of Bioanalysis

Poster presentations

2012

  • L. De Bock, K. Boussery, M. Van Winckel, P. De Paepe, X. Stephenne, E. Sokal, J. Van Bocxlaer. Cytochrome P450 activity in children with severe hepatic dysfunction: application of a UPLC-MS/MS method. International Conference on Mass spectrometry NVMS-BSMS. March 29-30, 2012. Kerkrade, the Netherlands. 

  • L. De Bock, K. Boussery, M. Van Winckel, P. De Paepe, X. Stephenne, E. Sokal, J. Van Bocxlaer. Hypervariable cytochrome P450 activity in children with severe hepatic dysfunction. 19th MDO and 12th European ISSX Meeting. June 17-21, 2012. Noordwijk-aan-Zee, the Netherlands.

2011

  • L. De Bock, K. Boussery, M. Van Winckel, P. De Paepe, X. Stephenne, E. Sokal, J. Van Bocxlaer. The influence of severe hepatic dysfunction on the metabolic capacity of the liver in children: Composition and characterization of a liver tissue bank. Annual Pharmacokinetics United Kingdom (PKUK) Meeting. November 9-11, 2011. Durham, United Kingdom.

2010

  • L. De Bock, K. Boussery, M. Van Winckel, P. De Paepe, J. Van Bocxlaer. The Influence of severe hepatic dysfunction on the metabolic capacity of teh liver in children: project plan. The Scientific afternoon of Faculty of Pharmaceutical Sciences. May 20, 2009. Ghent, Belgium.

  •  L. De Bock, K. Boussery, M. Van Winckel, P. De Paepe, E. Sokal, X. Stephenne, J. Van Bocxlaer. In vitro cytochrome P450 activity in children with severe hepatiic dysfunction: a UPLC-MS/MS method for the simultaneous quantification of six probe metabolites. Annual BSMS Meeting on Mass spectrometry. April 16, 2010. Woluwe, Belgium. and on The Scientific afternoon of Faculty of Pharmaceutical Sciences. May 12, 2010. Ghent, Belgium.

  •  S. Vande Casteele, L. De Bock, S. Mulliez, K. Boussery, J. Van Bocxlaer. Optimization of the derivatization of six probe metabolites for the in vitro determination of cytochrome P450 activity in children with hepatic impairment. The Scientific afternoon of Faculty of Pharmaceutical Sciences. May 12, 2010. Ghent, Belgium.

    2009

    • S. Cooreman, C. Deprez, F. Martens, J. Van Bocxlaer, and K. Croes.  A comprehensive LC-MS based quantitative analysis of fentanyl-like drugs in serum and urine.  Annual Symposium of the “Belgische Vereniging voor Klinische Biologie”. “Laboratory investigation of renal disease”.  October 17, 2009, Godinne-Yvoir, Belgium.

    • E. Joos, J. Van Bocxlaer, M. Vandermarliere, and K. Croes.  Simultaneous quantification of testosterone and androstenedione in human serum using LC-MS/MS.  9th FABIAN symposium “Socially Responsible Bioanalysis”.  November 10, 2009.  Weesp, The Netherlands.

    • L. De Bock, K. Boussery, M. Van Winckel, P. De Paepe, J. Van Bocxlaer. The  Influence of severe hepatic dysfunction on the metabolic capacity of the liver in children: project plan. The Scientific afternoon of Faculty of Pharmaceutical Sciences. May 20, 2009. Ghent, Belgium.

     2008

    • M. Van Winckel, J. De Smet, K. Boussery, P. De Cock, N. Huyghebaert, P. De Paepe, J.P. Remon and J. Van Bocxlaer.  Pharmacokinetic study of omeprazole Multi-Unit Pellet System (Losec MUPS®) versus extemporaneous bicarbonate formulation in patients with cerebral palsy. 11th biannual ESDP Congress, Rotterdam, The Netherlands, 4-7 juni 2008. 

    • R. t’Kindt, L. De Veylder, K. Morreel, D. Deforce, and J. Van Bocxlaer. Correla-tion between endoreduplication and metabolism in Arabidopsis thaliana: an LC- MS based metabolomics approach. Metabolomics Society's 4th Annual International Conference, Boston, Massachusetts, September 2-6, 2008. 

    • E. De Backer, R. t’Kindt,  I. Tency, R. Verhelst,  H. Verstraelen, M. Temmerman, D. Deforce, M. Vaneeckhoutte, and J. Van Bocxlaer. Analytical method optimization for a metabolomics study of human amniotic fluid. Metabolomics Society's 4th Annual International Conference, Boston, Massachusetts, September 2-6, 2008.

     

    2007

    • M. Storme and J. Van Bocxlaer.  Multi-trapping injection microLC-MS/MS for quantitative analysis of proteins based on tryptic marker peptides.  29th ISCC, Riva del Garda, Italy, May 29th – June 2nd 2007.

    • M. Storme, R. t’Kindt and J. Van Bocxlaer.  Evaluation of chemical digestion of proteins: an alternative to tryptic digestion in terms of reproducibility and efficiency. BSMS annual meeting, Leuven, February 16, 2007.

    • R. t’Kindt, M. Storme, N. Willemarck, K. Vleminckx, F. Van Roy, J. Swinnen and J. Van Bocxlaer.  Determination of cholesterol and cholesterol esters in Xenopus laevis embryo’s through direct flow injection electrospray ionisation mass spectrometry.  BSMS annual meeting, Leuven, February 16, 2007. 

    • M. Storme and J. Van Bocxlaer.  The use of acetonitrile for the extraction of low-molecular weight proteins: a worthy alternative for ultrafiltration.  HPLC 2007, Ghent, June 17-2, 2007. 

    • J. De Smet, W. Goeteyn, J.-P. Remon and J.F.P. Van Bocxlaer.  Determination of loratadine in dog plasma by high-performance liquid chromatography with fluorescence detection. 7th FABIAN symposium "De waarde van biomedische analyse: een wereld van verschil".   November 6, 2007.  Beerse, Belgium.

    • R. t’Kindt, M. Storme, W. Goeteyn and J. Van Bocxlaer.  Quantitative determination of glycopyrrolate in human plasma by liquid chromatography – electrospray ionization mass spectrometry.  7th FABIAN symposium "De waarde van biomedische analyse: een wereld van verschil".   November 6, 2007.  Beerse, Belgium.

    • Christof Van Poucke, Christ’l Detavernier, Jan F. Van Bocxlaer, Rudi Vermeylen and Carlos Van Peteghem.  The occurrence of benzene in soft drinks: a survey of the situation on the belgian market.   “3rd International Symposium on Recent Advances in Food Analysis”.  7-9 november 2007, Praag.

     

    2006

    • R. t’Kindt, R. Van Driessen, D. Deforce and J. Van Bocxlaer. Evaluation of HILIC in a metabolomic setup: comparison with a reversed-phase type of column. 4th International Conference on Plant Metabolomics. April 7-10, 2006. Reading, UK.

    • R. t’Kindt, J. Van Bocxlaer, L. De Veylder and D. Deforce. LC-MS based metabolomics and accurate mass measurements in complex extracts. 4th International Conference on Plant Metabolomics. April 7-10, 2006. Reading, UK.

     

    2005

    • M. Storme, D. Deforce, and J. Van Bocxlaer.  Optimization of an in solution tryptic digest protocol for use in quantitative LC/MS of proteins. Fourth FABIAN symposium “Bioanalyse & Biotechnologie”.  November 5, 2005. Ghent, Belgium.

    • R. t'Kindt, J. Van Bocxlaer, and D. Deforce.  Optimisation of LC-MS conditions for a metabolic approach.  Fourth FABIAN symposium “Bioanalyse & Biotechnologie”.  November 5, 2005. Ghent, Belgium.

    • R. Van Driessen, D. Deforce, and J. Van Bocxlaer.  Evaluation of the metabolic tool: MALDI-MS for the analysis of small molecules.  Fourth FABIAN symposium “Bioanalyse & Biotechnologie”.  November 5, 2005. Ghent, Belgium. 

    • B.S. Sinnaeve, and J.F. Van Bocxlaer.  Capillary-LC-MS/MS for the Quantification of Enkephalins.  Fourth FABIAN symposium “Bioanalyse & Biotechnologie”.  November 5, 2005. Ghent, Belgium.

    • B. Sinnaeve, K. Huvaere, D. De Keukeleire, and J. Van Bocxlaer.  Real Time Analysis of the Photooxidation of Beer Bittering Principles by Quadrupole Time-of-Flight Mass Spectrometry Combined with Headspace Gas Chromatography Mass Spectrometry.  Fourth FABIAN symposium “Bioanalyse & Biotechnologie”.  November 5, 2005. Ghent, Belgium.

    • Ben Geeraerts, Aline Dhondt, Laura Z. Rassenti, Dirk Elewaut, Jan F. Van Bocxlaer, Thomas J. Kipps and Dieter Deforce.  Differential proteome analysis of chronic lymphocytic leukemia subtypes.  XI iwCLL Conference, Sept. 16-18, 2005.  New York, NY, USA.

     

    2004

     

    • B.S. Sinnaeve and J.F. Van Bocxlaer.  Feasability of nanospray LC-MS/MS for the absolute quantification of peptides.    NVMS and BSMS PhD platform meeting, 21 april 2004, Tilburg, The Netherlands.

    • T.N. Decaestecker, C.H. Van Peteghem, D. Deforce, and J.F. Van Bocxlaer. Benchmarking of an IDA mediated LC-MS (/MS) GUS procedure.   NVMS and BSMS PhD platform meeting, 21 april 2004, Tilburg, The Netherlands.

    • A.V. Willems, D.L. Deforce, C.H. Van Peteghem, and J.F. Van Bocxlaer.  Development of a quality control method for the analysis of oligonucleotides by capillary zone electrophoresis-electrospray ionization mass spectrometry.  NVMS and BSMS PhD platform meeting, 21 april 2004, Tilburg, The Netherlands.

    • B. Geeraerts, L. Rassenti, J. Van Bocxlaer, W. Lambert, C. Van Peteghem, T.J. Kipps and D. Deforce.  Protein expression profiling of Chronic Lymphocytic Leukemia.  Subtypes with mutated or immutated Ig, VH genes including the ZAP-70 status.  Flanders Proteomics.  July 11, 2004.  Antwerp, Belgium.

    • A.V. Willems, D.L. Deforce, C.H. Van Peteghem, and J.F. Van Bocxlaer.  Analysis of oligonucleotides by capillary zone electrophoresis-electrospray ionization quadrupole time-of-flight mass spectrometry.  Abstracts of the 28th International Symposium and Exhibit on High Performance Liquid Phase Separations and Related Techniques.  2004, Philadelphia, PA, USA.

    • A.V. Willems, D.L. Deforce, C.H. Van Peteghem and J.F. Van Bocxlaer.  Development of a quality control method for the characterization of oligonucleotides by capillary liquid chromatography-nano-electrospray ionization quadrupole time-of-flight mass spectrometry.   Abstracts of the 28th International Symposium and Exhibit on High Performance Liquid Phase Separations and Related Techniques.  2004, Philadelphia, PA, USA.

    • T.N. Decaestecker, P.E. Wallemacq, C.H. Van Peteghem, and J.F. Van Bocxlaer.  An IDA mediated LC-MS/MS screening procedure with semi-quantitative potential.  TIAFT/SOFT meeting. 2004.  Washington DC, USA.

     

     

    2003

    • E.A. De Letter, M.F.A. Espeel, M.E.C. Craeymeersch, W.E. Lambert, J.F. Van Bocxlaer, M.M.A. Piette.  Immunohistochemical demonstration of the amphetamine derivatives 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylene-dioxyamphetamine (MDA) in human post-mortem tissues.  XIX Congress of the International Academy of Legal Medicine, Sept 3-6, 2003, Milan, Italy.

    • B.S. Sinnaeve, K. Clauwaert, and J.F. Van Bocxlaer.  Evaluation of nano-LC-MS/MS in a column switching setup as a tool for the absolute quantification of peptides in the picomolar range.  16th International Mass Spectrometry Conference, Aug. 31-Sept. 5, 2003, Edinburgh, Schotland.

    • A.V. Willems, D.L. Deforce, W.E. Lambert, C.H. Van Peteghem, J.F. Van Bocxlaer. Application of capillary zone electrophoresis-electrospray mass spectrometry for the characterization of oligonucleotides.  16th International Mass Spectrometry Conference, Aug. 31-Sept. 5, 2003, Edinburgh, Schotland. 

    • M.P. Bouche, P. Risha, C. Vervaet, C. Van Peteghem and J. Van Bocxlaer.  Combining selectivity from chromatography and fast ion separation by MS in bioanalysis: simultaneous determination of aspirin and salicylic acid in limited volume plasma samples by ESI(-)-LC-MS/MS.  16th International Mass Spectrometry Conference, Aug. 31-Sept. 5, 2003, Edinburgh, Schotland.

    • T.N. Decaestecker, W.E. Lambert, C.H. Van Peteghem, D. Deforce, and J.F. Van Bocxlaer.  LC-MS(/MS) based general unknown screening procedure (GUS) for drugs in blood using information dependent acquisition (IDA): pros and cons.  41th TIAFT Meeting, 16-20 november 2003, Melbourne, Australia.

    • K. Clauwaert, D. Deforce, C. Van Peteghem, M. Witt, and J. Van Bocxlaer.  The feasibility of Maldi-MS for small molecules as a future fast screening alternative in toxicology? preliminary results.  41th TIAFT Meeting, 16-20 november 2003, Melbourne, Australia.

     

    2002

    • A.V. Willems, D.L. Deforce, E.G. Van den Eeckhout, W.E. Lambert, C.H. Van Peteghem, A.P. De Leenheer and J.F. Van Bocxlaer.  The use of capillary zone electrophoresis-nano-electrospray mass spectrometry in conjunction with sample stacking for the detection and identification of DNA adducts.  Proceedings of the 25th International Symposium on Capillary Chromatography, Palazzo dei Congressi,  Riva del Garda, Italy, 14-17 mei 2002, Q10. 

    • A.V. Willems, D.L. Deforce, W.E. Lambert, C.H. Van Peteghem, A.P. De Leenheer and J.F. Van Bocxlaer.  Fast analysis of oligonucleotides by capillary liquid chromatography-nano electrospray mass spectrometry combined with column switching.  Proceedings of the 25th International Symposium on Capillary Chromatography, Palazzo dei Congressi, Riva del Garda, Italy, 14-17 mei 2002, Q 11.

    • B. Sinnaeve, T. Decaestecker, and J. Van Bocxlaer.  Analysis of ofloxacin in corneal deposits by microbore HPLC-tandem MS with electrospray ionisation.  Drug Analysis 2002, 21-25 April 2002, Brugge, Belgium.

    • M.P. Bouche, P. Risha, T. Decaestecker, C. Vervaet, C. Van Peteghem, and J. Van Bocxlaer. Fast Simultaneous Determination of the Anti-malarial Drugs, Pyrimethamine and Sulphadoxine, in Limited Volume Human Plasma Samples by LC-MS/MS.  50th ASMS conference on Mass Spectrometry and Allied Topics.  8-13 juni 2002, Orlando, Fl, USA.

    • M.P. Bouche, K. De Soete, L. Versichelen, M. Struys, G. Rolly, E. Mortier, and J. Van Bocxlaer.  In vitro evaluation of compound A stability in human whole blood.  7th Annual Meeting on Mass Spectrometry, BSMS, Sept. 2, 2002, Gent.

    • T. Decaestecker, M. Praisler, S. Vande Casteele, and J. Van Bocxlaer.  ESI or APCI to ionize pharmaceuticals: a chemometric approach.  7th Annual Meeting on Mass Spectrometry, BSMS, Sept. 2, 2002, Gent.

     

    2001

    • L. Versichelen, M.L. Bouche, M. Struys, J. Van Bocxlaer, G. Rolly, and E. Mortier.  No compound A with Superia® during minimal flow anaesthesia.  10 th European Society of Anaesthesiologists Anniversary meeting and 24th Euro-anaesthesia meeting, April 6-9, 2001, Nice, France.

     

    2000
     

    • K.M. Clauwaert, J.F. Van Bocxlaer, A. Willems, K. Mortier, W.E. Lambert, E.G. Van den Eeckhout, C. Van Peteghem, and A.P. De Leenheer.  Quantitation of amphetamine, methamphetamine, MDA, MDMA, and MDEA in saliva with a Q-TOF LC/MS/MS system.  38th triennial Meeting of The International Association of Forensic Toxicologists, August 13 - 17, Helsinki, Finland.

    • K. Arys, K. Clauwaert, B. De Craene, J. Claereboudt, W. Lambert, E. Van den Eeckhout, C. Van Peteghem, and J. Van Bocxlaer.  Electrospray orthogonal-acceleration time-of-flight mass spectrometry for the analysis of bis-quaternary muscle relaxants in forensic toxicology.  15th International Mass Spectrometry Conference, August 27 - September 1, 2000, Barcelona, Spain.

    • M.P. Bouche, J. Van Bocxlaer, G. Rolly, L. Versichelen, M. Struys, E. Mortier, W. Lambert, and A.P. De Leenheer.  Quantitative GC-MS of volatiles: compound A determinations in the vapor phase of sevoflurane based anesthesia systems.  15th International Mass Spectrometry Conference, August 27 - September 1, 2000, Barcelona, Spain.

    • T.N. Decaestecker, K.M. Clauwaert, J.F. Van Bocxlaer, W.E. Lambert, E.G. Van den Eeckhout, C.M. Van Peteghem, and A.P. De Leenheer.  Drug profiling analysis using the MS to MS/MS switching abilities of a Q-TOF.  5th Annual BSMS Meeting on Mass Spectrometry in pharmaceutical sciences.  Sept. 22, 2000, Braine-l’Alleud, Belgium.

    • M.P. Bouche, J. Van Bocxlaer, G. Rolly, L. Versichelen, M. Struys, E. Mortier, W. Lambert, and A. De Leenheer.  Quantitative GC-MS of volatiles: compound A determination in the vapor phase of sevoflurane based anesthesia systems.  5th Annual BSMS Meeting on Mass spectrometry in pharmaceutical sciences.  Sept. 22, 2000, Braine l’Alleud, Belgium.

    • K. Clauwaert, J. Van Bocxlaer, A. Willems, K. Mortier, W. Lambert, E. Van den Eeckhout, C. Van Peteghem, and A. De Leenheer.  The determination of amphetamine, methamphetamine, MDA, MDMA, and MDEA in saliva with LC/MS/MS.  5th Annual Meeting of the BSMS.  Mass spectrometry in pharmaceutical sciences.  Sept. 22, 2000.  Braine-l’Alleud, Belgium.

    • K. Clauwaert, J. Van Bocxlaer, T. Decaestecker, K. Mortier, W. Lambert, E. Van den Eeckhout, C. Van Peteghem, and A. De Leenheer.  Quantitation of cocaine, benzoylecgonine and cocaethylene in saliva with LC/MS/MS.  5th Annual BSMS Meeting.  Mass spectrometry in Pharmaceutical Sciences.  Sept. 22, 2000.  Braine-l’Alleud, Belgium (poster).

    • L. Versichelen, M. Struys, G. Rolly, M.P. Bouche, J. Van Bocxlaer.  KOH-free CO2 absorbent is not associated with less compound A production during in vitro sevoflurane.  12th World Congress of Anaesthesiologists, June 4-9, 2000, Montreal, Canada.

     

    1999

    • J.F. Van Bocxlaer, K.M. Clauwaert, W.E. Lambert, and A.P. de Leenheer. Segmental Hair Analysis for the determination of cocaine Abuse. 51th Meeting of the American Academy of Forensic Sciences.  Orlando, Fl, 15 - 20 februari 1999.

    • K.M. Clauwaert, J.F. Van Bocxlaer, W.E. Lambert, and A.P. de Leenheer. Cocaine Related Forensic Cases in the Flanders Region, Belgium : a Six Year Survey (1993-1998) of the Found Cocaine and Metabolite Concentrations. 51th Meeting of the American Academy of Forensic Sciences.  Orlando, Fl, 15 -20 februari 1999. 

    • G. Rolly, L. Versichelen, M.-P. Bouche, J. Van Bocxlaer, M. Struys, C. Van Der Herten, and A. De Leenheer. In vitro analysis of Compound A formation by sevoflurane in a computer controlled closed circuit Physioflex® Anesthesia Apparatus.  International Anesthesia Research Society, 73rd Clinical and Scientific Congres, 12 - 16 maart 1999, Beverly Hills, Los Angeles, USA. 

    • G. Rolly, L. Versichelen, M. Struys, M.P. Bouche, C. Van der Herten, J. Van Bocxlaer, and A. De Leenheer.  Compound A concentrations during quantitative closed circuit sevoflurane anaesthesia: an in vitro analysis.  European Society of Anaesthesiologists (ESA) Annual Congress, Amsterdam (NL), May 29 - June 1, 1999.  

    • K. Arys, J. Van Bocxlaer, W. Lambert, C. Van Peteghem, and A. De Leenheer. Comparison of an enzymatic alcohol dehydrogenase assay and alcohol headspace GC-FID method using statistical analysis on real forensic blood and urine samples. 37th triennial Meeting of The International Association of Forensic Toxicologists, 5-9 september, 1999, Krakau.  

    • I. Dirinck, M. Praisler, J. Van Bocxlaer, A. De Leenheer, and D.L Massart. Comparison between automated knowledge-based systems identifying and classifying amphetamine analogues using vapor-phase FTIR-spectra and mass spectra.  37th triennial Meeting of The International Association of Forensic Toxicologists, 5-9 september, 1999, Krakau. 

    • G. Rolly, L. Versichelen, M.-P. Bouche, M. Struys, and J. Van Bocxlaer. All closed anaesthesia circuits are not identical for compound A formation during in-vitro sevoflurane . American Society of Anaesthesiology (ASA) Annual meeting, Dallas (USA), 9-13 Oct. 1999. 

    • M.-P. Bouche, J. Van Bocxlaer, G. Rolly, L. Versichelen, and A. De Leenheer. Practical aspects of sampling and analysis for quantitative determination of Compound A during simulated closed circuit inhalation anaesthesia with sevoflurane. 4th Annual Symposium of the Association for Low Flow Anaesthesia. 2 - 3 sept. 1999, York, England.

    • M. Praisler, I. Dirinck, J. Van Bocxlaer, A. De Leenheer, and D.L Massart. Structural identification of sympathomimetic amines with GC-FTIR spectroscopy. 5th Chemometrics Symposium. 22 oktober 1999, Machelen, Belgium.  

    • I. Dirinck, M. Praisler, J. Van Bocxlaer, A. De Leenheer, and D.L Massart. Multivariate determination of the length of the side chain of illicit amphetamine analogues with GC-FTIR spectra. 5th Chemometrics Symposium. 22 oktober 1999, Machelen, Belgium.

    • M.P. Bouche, J. Van Bocxlaer, G. Rolly, L. Versichelen, and A.P. De Leenheer. Evaluation of Sevoflurane Toxicity during simulated Closed-Circuit Inhalation Anaesthesia by Quanitative Determination of Compound A using GC-MS. Najaarsmeeting van de Nederlandse Vereniging voor Massaspectrometrie. 16 nov. 1999. Oss, The Netherlands