Apr. Fauve Vergauwe

Apr. Fauve Vergauwe

Apr. Fauve Vergauwe

Laboratory of Pharmaceutical Microbiology (LPM)
Universiteit Gent
Ottergemsesteenweg 460
B-9000 Gent -Belgium

Tel: 32 - (0) 9 264 80 93
Fax: 32 - (0) 9 264 81 95

E-mail: Fauve.Vergauwe@ugent.be

list of publications

Fauve Vergauwe graduated in Pharmaceutical Sciences (Drug Development) in 2020 at Ghent University and started working at LPM in October that year.  The main focus of his research is the bacterium Propionibacterium acnes.

P. acnes is an important part of the normal human skin flora, naturally inhabiting the sebaceous follicles. As such, it plays an important role in the skin disease acne vulgaris. One of its most important virulence factors is the ability to form biofilms. A biofilm is an organized form of bacteria where they grow as aggregates surrounded by a polymer matrix in contrast to the independent, free-floating, planktonic state. When bacteria form a biofilm in a host, they become very resistant to treatment. There is evidence that in patients with acne, P. acnes forms more biofilm in the sebaceous follicles compared to people without acne. Besides its part in acne, P. acnes can also cause device-related infections, which are very difficult to treat and almost always result in the surgical removal of the device.

Since the existing models are far from the reality, a new in-vitro model will be developed better resembling the growth conditions in the human skin follicles. Later, the susceptibility of planktonic and sessile P. acnes isolates from diverse clinical samples will be tested against different existing and experimental therapies in this new model system.

In a later stage of the research, a cell based in vitro system will be developed where P. acnes biofilms will be cultured in the presence of sebocytes.