Publications

Overview of the different publications published by or in association with the Laboratory of Pharmaceutical Process Analytical Technology.

2014

  • Saerens, L.; Vervaet, C.; Remon, J.P., De Beer, T. (2014). Process monitoring and visualization solutions for hot-melt extrusion: A review. Journal of Pharmacy and Pharmacology, 66, 180-203.
  • Saerens, L.; Segher, N.; Vervaet, C.; Remon, J.P.; De Beer, T. (2014). Validation of an in-line Raman spectroscopic method for continuous active pharmaceutical ingredient quantification during pharmaceutical hot-melt extrusion. Analytica Chimica Acta, 806, 180-187.

2013

  • Fonteyne, M.; Fussell, A.L.; Vercruysse, J.; Vervaet, C.; Remon, J.P.; Strachan, C.; Rades, T.; De Beer, T. (2013). Distribution of binder in granules produced by means of twin screw granulation. International Journal of Pharmaceutics, 462, 8-10.
  • Hansen, L.; Pieters, S.; Montenez, J.P.; Daoussi, R.; Vander Heyden, Y.; Vervaet, C.; Remon, J.P.; De Beer, T. (2013). Near-infrared spectroscopic evaluation of lyophilized viral vaccine formulations. Biotechnology Progress, 29, 1573-1586.
  • Vercruysse, J.; Delaet, U.; Van Assche, I.; Cappuyns, P.; Arata, F.; Caporicci, G.; De Beer, T.; Remon, J.P.; Vervaet, C. (2013). Stability and repeatability of a continuous twin screw granulation and drying system. European Journal of Pharmaceutics and Biopharmaceutics, 85, 1031-1038.
  • Filipa Tavares da Silva, A.; Burggraeve, A.; Quenten, D.; Van der Meeren, P.; Sandler, N.; Van Den Kerkhof, T.; Hellings, M.; Vervaet, C.; Remon, J.P.; Lopes, J.; De Beer, T. (2013). Particle sizing measurements in pharmaceutical applications: comparison of in-process methods versus offline methods. European Journal of Pharmaceutics and Biopharmaceutics, 85, 1006-1018.
  • Mortier, S.T.F.C.; Van Hoey, S.; Cierkens, K.; Gernaey, K.V.; De Baets, B.; Seuntjes, P.; Nopens, I.; De Beer, T. (2013). A GLUE uncertainty analysis of a drying model of pharmaceutical granules. European Journal of Pharmaceutics and Biopharmaceutics, accepted. European Journal of Pharmaceutics and Biopharmaceutics, 85, 984-995.
  • Kumar, A.; Gernaey, K.V.; De Beer, T.; Nopens, I. (2013) Model-based analysis of high shear wet granulation from batch to continuous processes in pharmaceutical production – A critical review. European Journal of Pharmaceutics and Biopharmaceutics, 85, 814-832.
  • Vervaeck, A.; Saerens, L.; De Geest, B.G.; De Beer, T.; Carleer, R.; Adriaensens, P.; Remon, J.P.; Vervaet, C. (2013). Prilling of fatty acids as a continuous process for the development of controlled release of multiparticulate dosage forms. European Journal of Pharmaceutics and Biopharmaceutics, 85, 587-596.
  • Pieters, S.; Vander Heyden, Y.; Roger, J.M.; D'Hondt, M.; Hansen, L.; Palagos, B.; De Spiegeleer, B.; Remon, J.P.; Vervaet, C.; De Beer, T. (2013). Raman spectroscopy and multivariate analysis for the rapid discrimination between native-like and non-native states in freeze-dried protein formulations. European Journal of Pharmaceutics and Biopharmaceutics, 85, 263-271.
  • Saerens, L.; Vervaet, C.; Remon, J.P.; De Beer, T. (2013). Visualization and understanding of material behaviour in the extrusion barrel during a pharmaceutical hot-melt extrusion process using Raman spectroscopy. Analytical Chemistry, 85, 5420-5429.
  • Mortier, S.T.F.C.; Van Daele, T.; Gernaey, K.V.; Nopens, I.; De Beer, T. (2013). Reduction of a single granule drying model: an essential step in preparation of a PBM with a continuous growth term. AIChE Journal, 59, 1127-1138.
  • Mortier, S.T.F.C.; Gernaey, K.V.; Nopens, I.; De Beer, T. (2013). Development of a Population Balance Model of a pharmaceutical drying process and testing of solution methods. Computers & Chemical Engineering, 50, 39-53.
  • Fonteyne, M.; Vercruysse, J.; Diaz, D.C.; Gildemyn, D.; Vervaet, C.; Remon, J.P.; De Beer, T. (2013). Real-time assessment of critical quality attributes of a continuous granulation process. Pharmaceutical Development and Technology, 18, 85-97.
  • Burggraeve, A.; Monteyne, T.; Remon, J.P.; Vervaet, C.; De Beer, T. (2013). Process analytical tools for monitoring, understanding and control of pharmaceutical fluidized bed granulation: a review. European Journal of Pharmaceutics and Biopharmaceutics, 83, 2-15.
  • Pieters, S.; Saeys, W.; Van Den Kerkhof, T.; Goodarzi, M.; Hellings, M.; De Beer, T.; Vander Heyden, Y. (2013). Robust calibrations on reduced sample sets for API content prediction in tablets: Definition of a cost-effective NIR model development strategy. Analytica Chimica Acta, 761, 62-70.

2012

  • Almeida, A.; Saerens, L.; De Beer, T.; Remon, J.P.; Vervaet, C. (2012). Upscaling and in-line process monitoring via spectroscopic techniques of ethylene vinyl acetate hot-melt extruded formulations. International Journal of Pharmaceutics, 439, 223-229.
  • Quinten, T.; Andrews, G.P.; De Beer, T.; Saerens, L.; Bouquet, W.; Jones, D.S.; Hornsby, P.; Remon, J.P.; Vervaet, C (2012). Preparation and evaluation of sustained-release matrix tablets based on metoprolol and an acrylic carrier using injection moulding. AAPS PharmSciTech, 13, 1197-1211.
  • Almeida, A.; Brabant, L.; Siepmann, F.; De Beer, T.; Bouquet, W.; Van Hoorebeke, L.; Siepmann, J.; Remon, J.P.; Vervaet, C. (2012). Sustained release from hot-melt extruded matrices based on ethylene vinyl acetate and polyethylene oxide. European Journal of Pharmaceutics and Biopharmaceutics, 82, 526-533.
  • Fonteyne, M.; Soares, S.; Vercruysse, J.; Peeters, E.; Burggraeve, A.; Vervaet, C.; Remon, J.P.; Sandler, N.; De Beer, T. (2012). Prediction of quality attributes of continuously produced granules using complementary PAT tools. European Journal of Pharmaceutics and Biopharmaceutics, 82, 429-436.
  • Burggraeve, A.; Vander Heyden, Y.; Silva, A. F. T.; Van Den Kerkhof, T.; Hellings, M.; Vervaet, C.; Remon, J. P.; De Beer, T. (2012) Development of a fluid bed granulation control strategy based on real-time process and product measurements. Talanta, 100, 293-302.
  • Aksu, B.; De Beer, T.; Folestad, S.; Ketolainen, J.; Lindén, H.; Almeida Lopes, J.; de Matas, M.; Oostra, W.; Rantanen, J.; Weimer, M. (2012). Strategic funding priorities in the pharmaceutical sciences allied to Quality by Design (QbD) and Process Analytical Technology (PAT). European Journal of Pharmaceutical Sciences, 47, 402-405.
  • Vercruysse, J.; Cordoba Diaz, D.; Peeters, E.; Fonteyne, M.; Delaet, U.; Van Assche, I.; De Beer, T.; Remon, J.P.; Vervaet, C. (2012). Continuous twin screw granulation: influence of process variables on granule and tablet quality. European Journal of Pharmaceutics and Biopharmaceutics, 82, 205-211.
  • Dierickx, L.; Saerens, L.; Almeida, A.; De Beer, T.; Remon, J.P.; Vervaet, C. (2012). Co-extrusion as manufacturing technique for fixed-dose combination mini-matrices. European Journal of Pharmaceutics and Biopharmaceutics, 81, 683-689.
  • Mortier, S.T.; De Beer, T.; Gernaey, K.; Vercruysse, J.; Fonteyne, M.; Remon, J.P.; Vervaet, C.; Nopens, I. (2012). Mechanistic modelling of the drying behaviour of single pharmaceutical granules. European Journal of Pharmaceutics and Biopharmaceutics, 80, 682-689.
  • Saerens, L.; Dierickx, L.; Quinten, T.; Adriaensens, P.; Carleer, R.; Vervaet, C.; Remon, J.P.; De Beer, T. (2012). In-line NIR spectroscopy for the understanding of polymer-drug interaction during pharmaceutical hot-melt extrusion. European Journal of Pharmaceutics and Biopharmaceutics, 81, 230-237.
  • Huyghe, K.; Van Reeth, K.; De Beer, T.; Landman, W.J.; van Eck, J.H.; Remon, J.P.; Vervaet, C. (2012). Suitability of differently formulated dry powder Newcastle disease vaccines for mass vaccination of poultry. European Journal of Pharmaceutics and Biopharmaceutics, 80, 649-656.
  • Mehta, S.; De Beer, T.; Remon, J.P.; Vervaet, C. (2012). Effect of desintegrants on the properties of multiparticulate tablets comprising starch pellets and excipient granules. International Journal of Pharmaceutics, 422, 310-317.
  • Pieters, S.; De Beer, T.; Kasper, J.C.; Boulpaep, D.; Friess, W.; Remon, J.P.; Vervaet, C.; Waszkiewics, O.; Goodarzi, M.; Tistaert, C.; Vander Heyden, Y. (2012). Near-infrared spectroscopy for in-line monitoring of protein unfolding and its interactions with lyoprotectants during freeze-drying. Analytical Chemistry, 84, 947-955.

2011

  • Burggraeve, A.; Sandler, N.; Heinämäki, J.; Räikkönen, H.; Remon, J.P.; Vervaet,C.; De Beer, T.R.M.; Yliruusi, J. (2011). Real-time image-based investigation of spheronization and drying features of different formulations using different pellet formulations. European Journal of Pharmaceutical Sciences, 44, 635-642.
  • De Beer, T.; Burggraeve, A.; Fonteyne, M; Saerens, L.;  Vervaet, C.; Remon, J.P. (2011). Near infrared and Raman spectroscopy for the in-process monitoring of Pharmaceutical production processes. International Journal of Pharmaceutics, 417, 32-47.
  • Mortier, S.T.; De Beer, T.; Gernaey, K.V.; Remon, J.P.; Vervaet, C.;  Nopens, I. (2011). Mechanistic modelling of fluidized bed drying processes of wet porous granules: A review. European Journal of Pharmaceutics and Biopharmaceutics, 79, 205-225.
  • Sacré, P.Y.; Deconinck, E.; Saerens, L.; De Beer, T.; Courselle, P.; Vancauwenberghe, R.; Chiap, P.; Crommen, J.; De Beer, J.O. (2011). Detection of counterfeit Viagra® by Raman microspectroscopy imaging and multivariate analysis. Journal of Pharmaceutical and Biomedical Analysis, 56, 454-461.
  • Quinten, T.; De Beer, T.; Onofre, F.O.; Mendez-Montealvo, G.; Wang, Y. J.; Remon, J.P.; Vervaet, C. (2011). Sustained-release and swelling characteristics of xanthan gum/ethylcellulose based injection moulded matrix tablets: in vitro and in vivo evaluation. Journal of Pharmaceutical Sciences, 100, 2858-2870.
  • De Temmerman, M.L.; Rejman, J.; Grooten, J.; De Beer, T.; Vervaet, C.; Demeester, J.; De Smedt, S.C. (2011). Lyophilization of protein-loaded polyelectrolyte microcapsules. Pharmaceutical Research, 28, 1765-1773.
  • Na, N.; Cui, X.; De Beer, T.; Liu, T.; Tang, T.; Sajid, M.; Ouyang, J.(2011). The use of silica nanoparticles for gas chromatographic separation. Journal of Chromatography A, 1218, 4552-4558.
  • Burggraeve, A.; Van Den Kerkhof, T.; Hellings, M.; Remon, J.P.; Vervaet, C.; De Beer, T. (2011) Batch statistical process control of a fluid bed granulation process using in-line spatial filter velocimetry and product temperature measurements. European journal of Pharmaceutical Sciences, 42, 584-592
  • Almeida, A.; Possemiers, S.; Boone, M.; De Beer, T.; Quinten, T.; Van Hoorebeke, L.; Remon, J.P.; Vervaet, C. (2011). Ethylene Vinyl Acetate as Matrix for Oral Sustained Release Multiple-Unit Dosage Forms Produced via Hot-Melt Extrusion. European Journal of Pharmaceutics and Biopharmaceutics, 77, 297-305.
  • Quinten, T.; De Beer, T.; Almeida, A.; Vlassenbroeck, J.; Van Hoorebeke, L.; Remon, J.P.; Vervaet, C. (2011). Development and Evaluation of Injection Moulded Sustained Release Tablets Containing Ethylcellulose and Polyethelyne Oxide. Drug Development and Industrial Pharmacy, 37, 149-159.
  • De Beer, T.R.M.; Wiggenhorn, M.; Hawe, A.; Kasper, J.C.; Almeida, A.; Quinten, T.; Friess, W.; Winter, G.;  Vervaet, C.; Remon, J.P. (2011). Optimisation of a pharmaceutical freeze-dried product and its process using an experimental design approach and innovative process analysers. Talanta, 83, 1623-1633.
  • Saerens, L.; Dierickx, L.; Lenain, B.; Vervaet, C.; Remon, J.P.; De Beer, T. (2011). Raman spectroscopy for the in-line polymer-drug quantification and solid-state characterization during a pharmaceutical hot-melt extrusion process. European Journal of Pharmaceutics and Biopharmaceutics, 77, 158-163.

2010

  • Sacré, P.Y.; Deconinck, E.; De Beer, T.; Courselle, P.; Vancauwenberghe, R.; Chiap, P.; Crommen, J.; De Beer, J. (2010). Comparison and combination of spectroscopic techniques for the detection of counterfeit medicines. Journal of Pharmaceutical and Biomedical Analysis, 53, 445-453.
  • Sarraguça, M.C.; De Beer, T.; Vervaet, C.; Remon, J.P.; Almeida Lopes, J. (2010). A batch modeling approach to monitor a freeze-drying process using in-line Raman spectroscopy. Talanta, 83, 130-138.
  • de Waard, H.; De Beer, T.; Hinrichs, W.L.J.; Vervaet, C.; Remon, J.P.; Frijlink, H.W. (2010). In-Line Raman Spectroscopy to Reveal the Mechanism of Controlled Crystallization of a Lipophilic Drug During Freeze-Drying. AAPS Journal, 12, 569-575.
  • Burggraeve, A.; Van Den Kerkhof, T.; Hellings, M.; Remon, J.P.; Vervaet, C.; De Beer, T. (2010) Evaluation of in-line spatial filter  velocimetry as PAT monitoring tool for particle growth during fluid  bed granulation. European Journal of Pharmaceutics and  Biopharmaceutics, 76, 138-146

2009

  • Verhoeven, E.; Siepmann, F.; De Beer, T.R.M.; Van Loo, D.; Van den Mooter, G.; Remon, J.P.; Siepmann, J.; Vervaet, C. (2009). Modeling Drug Release from Hot-Melt Extruded Mini-Matrices with Constant and non-Constant Diffusivities. European Journal of Pharmaceutics and Biopharmaceutics, 73, 292-301.
  • De Beer, T.R.M.; Wiggenhorn, M.; Veillon, R.; Debacq, C.; Mayeresse, Y.; Moreau, B.; Burggraeve, A.; Quinten, T.; Frieβ, W.; Winter, G.; Vervaet, C.; Remon, J.P.; Baeyens, W.R.G. (2009). The Importance of Using Complementary Process Analyzers for the Process Monitoring, Analysis and Understanding of Freeze Drying. Analytical Chemistry, 81, 7639-7649.
  • Quinten, T.; Gonnissen, Y.; Adriaens, E.; De Beer, T.R.M.; Cnudde, V.; Masschaele, B.; Van Hoorebeke, L.; Siepmann, J.; Remon, J.P.; Vervaet, C. (2009). Development of injection moulded matrix tablets based on mixtures of ethylcellulose and low-substituted hydroxypropylcellulose. European Journal of Pharmaceutical Sciences, 37, 207-216.
  • Cosijns, A.; Nizet, D.; Nikolakakis, I.; Vervaet, C.; De Beer, T.R.M.; Siepmann, F.; Siepmann, J.; Evrard, B.; Remon, J.P. (2009). Porous pellets as drug delivery system. Drug Development and Industrial Pharmacy, iFirst, 1-8.
  • Verhoeven, E.; De Beer, T.R.M.; Schacht, E.; Van den Mooter, G.; Remon, J.P.; Vervaet, C. (2009). Influence of polyethylene glycol/polyethylene oxide on the release characteristics of sustained-release ethylcellulose mini-matrices produced by hot-melt extrusion: in vitro and in vivo evaluations. European Journal of Pharmaceutics and Biopharmaceutics, 72, 463-470.
  • De Beer, T.R.M.; Vercruysse, P.; Burggraeve, A.; Quinten, T.; Ouyang, J.; Zhang, X.; Vervaet, C.; Remon, J.P.; Baeyens, W.R.G. (2009). In-line and real-time process monitoring and control of a freeze drying process using Raman and NIR spectroscopy as complementary process analytical technology (PAT) tools. Journal of Pharmaceutical Sciences, 98, 3430-3446.
  • De Veij, M.; Vandenabeele, P.; De Beer, T.R.M.; Remon, J.P.; Moens, L. (2009). Reference database of Raman spectra of pharmaceutical excipients. Journal of Raman Spectroscopy, 40, 297-307.

2008

  • Quinten, T.; De Beer, T.R.M.; Vervaet, C.; Remon, J.P (2009). Evaluation of injection moulding as a pharmaceutical technology to produce matrix tablets. European Journal of Pharmaceutics and Biopharmaceutics, 71, 145-154.
  • Dukić-Ott, A.; De Beer, T.R.M.; Remon, J.P.; Baeyens, W.; Foreman, P.; Vervaet, C (2008). In-vitro and in-vivo evaluation of enteric-coated starch-based pellets prepared via extrusion/spheronisation. European Journal of Pharmaceutics and Biopharmaceutics, 70, 302-312.
  • De Beer, T.R.M.; Bodson, C.; Dejaegher, B.; Walczak, B.; Vercruysse, P.; Burggraeve, A.; Lemos, A.; Delattre, L.; Vander Heyden, Y.; Remon, J.P.; Vervaet, C.; Baeyens, W.R.G. (2008). Raman spectroscopy as a process analytical technology (PAT) tool for the in-line monitoring and understanding of a powder blending process. Journal of Pharmaceutical and Biomedical Analysis, 48, 772-779.
  • Verhoeven, E.; De Beer, T.R.M.; Van den Mooter, G.; Remon, J.P.; Vervaet, C. (2008). Influence of formulation and process parameters on the release characteristics of ethylcellulose sustained-release mini-matrices by hot-melt extrusion. European Journal of Pharmaceutics and Biopharmaceutics, 69, 312-319.

2007

  • De Beer, T.R.M.; Allesø, M.; Baeyens, W.R.G.; Vander Heyden, Y.; Lopez de Diego, H.; Rantanen, J.; Vervaet, C.; Remon J.P. (2007). Raman spectroscopy as a process analytical technology (PAT) tool for the in-line monitoring and understanding of freeze drying processes. Analytical Chemistry, 79, 7992-8003.
  • De Beer, T.R.M.; Baeyens, W.R.G.; Vervaet, C.; Remon, J.P. (2007). A strategy to implement a PAT system in a pharmaceutical production process. A case study: freeze-drying. STP Pharma Pratiques, 17, 167-169.
  • De Beer, T.R.M.; Baeyens, W.R.G.; Vermeire, A.; Broes, D.; Remon, J.P.; Vervaet, C. (2007). Raman spectroscopic method for the determination of medroxyprogesterone acetate in a pharmaceutical suspension: validation of quantifying abilities, uncertainty assessment and comparison with the HPLC reference method. Analytica Chimica Acta, 589, 192-199.
  • De Beer, T.R.M.; Baeyens, W.R.G.; Vander Heyden, Y.; Remon, J.P.; Vervaet, C.; Verpoort, F. (2007). Influence of particle size on the quantitative determination of salicylic acid in a pharmaceutical ointment using FT-Raman spectroscopy. European Journal of Pharmaceutical Sciences, 30, 229-235.

2006

  • De Beer, T.R.M.; Baeyens, W.R.G.; Ouyang, J.; Vervaet, C.; Remon, J.P. (2006). Raman spectroscopy as a process analytical technology tool for the understanding and the quantitative in-line monitoring of the homogenization process of a pharmaceutical suspension. The Analyst, 131, 1137-1144.

2004

  • De Beer, T.R.M.; Vergote, G.J.; Baeyens, W.R.G.; Remon, J.P.; Vervaet, C.; Verpoort, F. (2004). Development and validation of an innovative, direct quantitative method for medroxyprogesterone acetate in a pharmaceutical suspension using FT-Raman spectroscopy. European Journal of Pharmaceutical Sciences, 23, 355-362.
  • Vergote, G.J.; De Beer, T.R.M.; Vervaet, C.; Remon, J.P.; Baeyens, W.R.G.; Dierickx, N.; Verpoort, F. (2004). In-line monitoring of a pharmaceutical blending process using FT-Raman spectroscopy. European Journal of Pharmaceutical Sciences, 21, 479-485.