Tsolmon Erelkhegbaatar

As the pharmaceutical industry transitions toward continuous manufacturing, there is a growing need for advanced process knowledge and control strategies to ensure consistent product quality. Continuous fluid bed granulation (FBG) represents a promising technology for the production of oral solid dosage forms. In FBG, granules are produced in a single piece of equipment by spraying a binder solution onto a fluidized powder bed. Despite its potential, the process remains complex due to the dynamic interactions between air, liquid, and solid particles.

This project aims to gain a thorough understanding of how process parameters influence granule quality. Additionally, the research aims to establish a procedure that enables a transition between continuous and batch manufacturing, thereby supporting manufacturing flexibility. A central objective is the development of a PAT control strategy to enable real-time process control and enhance overall process robustness.

Ultimately, this work aims to contribute to the broader adoption of continuous manufacturing in the pharmaceutical industry.