M. tuberculosis thymidylate kinase inhibitors (on hold)

In search for better TB drugs we  have synthesized a number of promising inhibitors of M. tuberculosis thymidine monophosphate (thymidylate) kinase (TMPKmt), an attractive target for blocking mycobacterial DNA synthesis. The 3D structure of this enzyme proved a valuable tool for inhibitor design. Unfortunately, translating these inhibitors into leads with in vitro antimycobacterial activity was not obvious.