Calcium Signaling in Health, Disease and Therapy (CaSign)

Physiology Group


Project 5

Calcium Signaling in Health, Disease and Therapy (CaSign)


This Scientific Research Network brings together three important research teams active in Flanders and different leading international research teams with a unique focus on the role of Ca2+ signaling in cell function and cell death/survival underlying health, disease and therapy. Research within this network specifically focuses on

  1. the molecular regulation of calcium-flux systems by oncogenes and tumor suppressors,
  2. the physiological role of Bcl-2-family members in excitable cell systems related to the heart, brain and pancreas,
  3. calcium signaling and Bcl-2 function in cancer and anti-cancer strategies and
  4. modulation of calcium signaling as a strategy for improved oocyte survival.

Funding Ageny

Research Foundation - Flanders (FWO) sponsored Scientific Research Network 2017-2021, PI Prof. Geert Bultinck, KULeuven in collaboration with Luc Leybaert, UGent and Prof. Llewelyn Roderick, KULeuven.
External members: Prof. David Yule, University of Rochester (US), Prof. Irina Serysheva, University of Texas (US), Prof. Varda Shoshan-Barmatz, Ben-Gurion University (IL), Prof. Oleg Gerasimenko, Cardiff University (GB), Prof. Paolo Pinton, University of Ferrara (IT), Prof. Katsuhiko Mikoshiba, RIKEN, Saitama (JP), Prof. Nathalia Preverskaya, University of Lille (FR), Prof. Christian Soeller, University of Exeter (GB), Prof. Ulrich Giesen, Physikalisch Technische Bundesanstalt (DE), Fabio Mammano, National Research Council, Rome (IT) and Prof. Geneviève Dupont, ULB (BE)


Luc Leybaert