Anesthesiology and Perioperative Medicine

The department provides research at two levels. The basic experimental part focuses on cardiac physiology, electrophysiology, and pharmacology in an experimental animal model. The applied clinical part focuses on human physiology and its application in designing strategies to improve perioperative outcome. Another part of the clinical research focuses on pharmacodynamic and pharmacokinetic models (closed loop) of anesthetic drugs. Finally, the department is heavily involved in international multicenter studies on perioperative medicine.

Current Projects

• Dynamic Filling Parameters in the Perioperative Period

• Application of Trial Sequential Analysis (TSA) in Perioperative Literature

• Effects of Propofol a Sevoflurane on Hepatic Blood Flow during Goal-Directed Hemodynamic Therapy

• Effects of Noradrenaline on Hepatic Blood Flow during Goal-Directed Hemodynamic Therapy

• Effects of Nitroglycerine on Hepatic Blood Flow during Goal-Directed Hemodynamic Therapy

• Development of a Prediction Model for Occurrence of Renal Failure after Hepatic Surgery

• Effects of Ephedrine and Phenylephrine on Cerebral and Spinal Tissue Oxygen Saturation Measured with Near-Infrared Spectroscopy

• Effects of Dobutamine and Phenylephrine on Cerebral and Spinal Tissue Oxygen Saturation Measured with Near-Infrared Spectroscopy

• Digital Patient Platform: Application In Surgical Day Case Clinic

• Evaluation of Applicability of Routinely Used Clinical Monitoring To Assess Right Ventricular Cardiac Performance

• Effects of Psychological Factors on The Chronification of Pain Process

• Evaluation of a New Non-Invasive Pain Monitor ANSPEC-PRO

• Validation of the Bispectral Index Controlled Bayesian-Based Closed-Loop System in Different Circumstances

• CO2 Absorbent Usage Measured by CO2 Mass Balances in the Circle Breathing System Versus Titration

• In Vitro Testing of Memsorb, a Novel Membrane CO2 Absorber, with the Zeus Anesthesia Machine

• In Vivo Testing of Memsorb, a Novel Membrane CO2 Absorber, during Target Controlled Low Flow Delivery with the Zeus

• Desflurane Usage at Equipotent Concentrations with the Flow-i, Zeus, and Aisys used in Target Controlled Low Flow Mode

• Does an Increase in Inspired CO2 Alter the CO2 A-a Gradient?

Finalized Projects

Overview

Infrastructure and techniques

• Hemodynamic Monitoring: Pressure Catheters, Transesopheal Echocardiography
• Depth of Anesthesia Monitoring: BIS
• Tissue Oxygen Saturation Monitoring
• Blood Flow Measurement

Staff

Prof. Dr. Patrick Wouters, Chair of the Department of Fundamental and Applied Medical Sciences

Prof. Dr. Stefan De Hert, research coordinator

Prof. Dr. Luc De Baerdemaeker | Prof. Dr. Annelies Moerman | Prof. Dr. Marc Coppens | Prof. Dr. Michel Struys | Prof. Dr. Theo Meert

Dr. Jurgen van Limmen | Dr. Björn Heyse | Dr. Piet Wyffels | Dr. Caroline Vanpeteghem | Dr. Michael Van den Heuvel | Dr. Pieter Verslype | Dr. Martine Neckebroek | Dr. Aliaksandra Paraschanka

Dr. Jan Hendrickx

Contact

Stefan De Hert, cfr Research Explorer.