Polymer-based materials for tissue engineering applications

About this line of research

We collaborate with PBM group to develop new scaffolds and bioinks based on gelatin, shape-memory polymers and biopolymers for tissue engineering.

We aim to address the design of biocompatible tissue engineering materials, which can interact and respond to the needs of the growing tissues and organs, in vitro and in vivo. Using our own concept of ‘biosensor scaffold materials’, we gain a deeper understanding of cell oxygenation and important biomolecule gradients (pH, Ca2+, others) in Matrigel-grown intestinal organoids and 3D tumour tissue models.

We also collaborate with international experts in biosensor research and microscopy, in order to develop improved nanosensors for imaging O2, T and pH in live 3D tissues.

Publications

  1. Okkelman IA, McGarrigle R, O'Carroll S, Carvajal Berrio D, Schenke-Layland K, Hynes J, Dmitriev RI: Extracellular Ca2+-sensing fluorescent protein biosensor based on a collagen-binding domain. ACS Applied Bio Materials 2020. DOI: 10.1021/acsabm.0c00649
  2. O'Donnell N, Okkelman IA, Timashev P, Gromovykh TI, Papkovsky DB, Dmitriev RI: Cellulose-based scaffolds for fluorescence lifetime imaging-assisted tissue engineering. Acta Biomaterialia 2018, 80, 85-96.
  3. Kawashima M, Bensaad K, Zois CE, Barberis A,  Bridges E,  Wigfield S,  Lagerholm C,  Dmitriev RI, Tokiwa M,  Toi M,  Papkovsky DB,  Buffa FM, Harris AL: Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells. Cancer & Metabolism 2020, 8 (1), 13.
  4. *Müller BJ, Zhdanov AV, Borisov SM, Foley T, Okkelman IA, Tsytsarev V, Tang Q, Erzurumlu RS, Chen Y, Zhang H, Toncelli C, Klimant I, Papkovsky DB, Dmitriev RI: Nanoparticle-Based Fluoroionophore for Analysis of Potassium Ion Dynamics in 3D Tissue Models and In Vivo. Advanced Functional Materials 2018. DOI: 10.1002/adfm.201704598.
  5. *Jenkins J., Borisov S.M., Papkovsky D.B., Dmitriev R.I.: Sulforhodamine nanothermometer for multi-parametric FLIM imaging. Analytical Chemistry 2016, 88, 10566-10572.

Questions?

  • Ruslan Dmitriev, professor/head of the group

+32 9 332 51 33