Flowsheet modelling for pharmaceutical manufacturing processes

Target audience

PhD candidates affiliated to the Faculty of Pharmaceutical Science or Bioscience Engineering, who are familiar with some pharmaceutical processes, and have interest in modelling techniques. Modelling experience is not required, but some programming experience will help. 

Organizing and scientific committee

Dr. Kensaku Matsunami

Prof. Dr. Ashish Kumar


Flowsheet modelling is a method used to visually represent and mathematically analyse the entire manufacturing process consisting of multiple unit operations. This method is valuable for pharmaceutical processes, especially continuous manufacturing, to optimise processes and formulations based on the final product and understand the propagation of variabilities. In this doctoral school course, you will learn the application of flowsheet modelling to oral solid dosage manufacturing (e.g., continuous direct compression process).


  • Understand the value of flowsheet modelling for a pharmaceutical application.
  • Learn existing unit operation models of oral solid dosage manufacturing.
  • Develop a flowsheet model using the software gPROMS.
  • Study advanced analyses (e.g., sensitivity analysis) for process understanding.
  • Understand the impact of processes and formulations mechanistically.

Dates and venue

22 and 23 February 2024


Day 1 (22 February, 2024)

  • 8:30 – 9 am: Introduction of the course
  • 9 - 10 am: General introduction of flowsheet modelling and digital twin (Prof. Ashish Kumar)
  • 10 – 11 am: Pharmaceutical unit operations and manufacturing routes (Prof. Ashish Kumar)
  • 11 am – 12 pm: Modelling of continuous direct compression (feeding, blending, and compression) (Dr. Kensaku Matsunami)
  • 12 – 1 pm: Lunch (meals will be provided)
  • 1 – 2 pm: Introduction of simulation software: gPROMS (Dr. Kensaku Matsunami)
  • 2 – 5 pm: Simulation exercise of continuous direct compression, including optimisation of unit operation models and flowsheet modeling (Dr. Kensaku Matsunami)

Day 2 (23 February, 2024)

  • 8:30 – 10 am: Lectures on advanced analyses (e.g., global sensitivity analysis)
  • 10 am – 12 pm: Exercises in advanced analysis
  • 12 – 1 pm: Lunch (meals will be provided)
  • 1 – 2 pm: Flowsheet modeling of other manufacturing routes (e.g., wet granulation)
  • 2 – 3 pm: Control strategy using a flowsheet model
  • 3 -4 pm: Exercise on control strategy using a flowsheet
  • 4 – 5 pm: Discussion and conclusion

*Participants are expected to install the software “gPROMS” beforehand. Information on the installation procedure will be sent to the participants. 


Follow this link for the registration and waiting list. 

Cancellation of your registration can only be performed by sending an email to doctoralschools@ugent.be.

Registration fee

Free of charge for Doctoral School members.

The no show policy applies.

Number of participants

Maximum 25



Evaluation method

100% attendance, active participation and report of exercise.

After successful participation, the Doctoral Schools will add this course to your curriculum of the Doctoral Training Programme in Oasis. Please note that this can take up to one to two months after completion of the course.