PhD dissertations

 

Name	Date	Title
Xialong Xu	Jan 2020	Title: Quality characterization of raw materials used in advanced therapy medicinal products: HEPES, APMg and album
Han Yao	Oct 2019	Title: Quality exploration of L-asparaginase: analytical characterization
Steven Janvier	Jan.2019	Title: Hazard analysis of falsified peptide 'medicines'
Bert Gevaert	Jan 2017	Exploration of cryptic peptides: analytical, pharmacoloical and regulatory contributions
Sultan Suleman	Feb 2016	Quality of selected medicines in Ethiopia: analytical and regulatory contribution
Nathalie Bracke	Dec 2016	Functional quality of somatropin derivatives: NOTA-modifications and peptides
Lieselotte Veryser	Oct 2016	Analytical, pharmacokinetic and regulatory characterisation of selected plant N-alkylamides
Lien Taevernier	Sept 2016	Skin, mucosal and blood-brain barrier kinetics of model cyclic depsipeptides: the mycotoxins beauvericin & enniatins
Sofie Stalmans	Sept 2015	To what extent do cell-penetrating peptides selectively cross the blood-brain barrier?
Matthias D'Hondt	Jan 2015	Towards a peptide implant: analytics, dry heat behavior and functional characterization.
Evelien Wynendaele	Dec 2014	Exploration of quorum sensing peptides : the missing link between microbiome and cancer outcome ?
Antita Adriaens	Dec 2013	Morphine and the canine brain: The influence of morphine on cerebral perfusion and 5-HT2A receptors. Promotor: prof. I. Polis; Co-promotor: prof. B. De Spiegeleer
Jente Boonen	Dec 2012	Functional quality of spilanthol, a plant N-alkylamide for dermal applications
Sylvia Van Dorpe	Feb 2012	Analytical characterization of the  blood-brain barrier transport of peptides
Bram Baert	Jan 2011	Functional quality of tropical drugs: analytical exploration of the Franz Diffusion Cell test.
Adel Pezeshki	Dec 2010	Physiology and pathophysiology of the mammary gland in primiparous cows with special emphasis to dry period length and experimental E.coli mastitis. Promotor: prof. C. Burvenich; Co-promotor: prof. B. De Spiegeleer
Valentijn Vergote	Feb 2010	Quality analytics of peptide drugs: the obestatin case.

 

Master dissertations

 

• Hannah Hirmz

“Alleviating peptide adsorption: an ecological and financially sustainable anti-adsorption diluent alternative.” (2020)

• Merel Wauters

“Effects of selected QSPs on host muscle.” (2020)

• Sebastiaan Dhaenens

“Presence of EntF metabolite in human faeces.” (2020)

• Phaedra Snauwaert

“Target elucidation of the EntF metabolite in HCT-8 cells.” (2020)

• Ella Vancraeynest

“Photolysis of CgCPA for selective therapy: principles and UPLC method development.” (2020)

• Arnout Swaenen

“Development of a fusion peptide for miRNA-21 targeted treatment of Glioblastoma Multiforme.” (2020)

• Yani Ongena

“Het effect van quorum sensing peptiden op BV-2 microglia en SH-SY5Y neuroblasten.” (2019)

• Amélie Descamps

“Solid-phase synthesis and quality control of quorum sensing peptide derivatives.” (2019)

• Margot Poelman

“Kwaliteitscontrole voor NOTA-somatropine en Ga-NOTA-somatropine.” (2019)

• Dorian Depuydt

“Detectie en stabiliteit van quorum sensing peptiden in biologische matrices.” (2019)

• Van Langenhove Selien

“Quorum sensing moleculen en sarcopenie: in vitro proof-of-concept.” (2019)

• Djoa Jacintha

“Verklaren van de MTT effecten van geselecteerde quorum sensing peptiden op C2C12 cellen.” (2019)

• Shary Hermans

“HILIC and RP-chromatography for the detection of quorum sensing peptides.” (2018)

• Charlotte Masschelein

“Perceptions of pharmacists in West-Flanders towards probiotics.” (2018)

• Karen Herman

“Human Albumin and L-Ascorbic Acid 2-Phosphate Magnesium Salt as Raw Materials in the ATMP Production Process: Quality Assessments.” (2018)

• Miguel Colpaert

“In pursuit of quality medicines: Residual API on packaging as GMP-marker?” (2018)

• Shauni Patyn

“The influence of bacterial quorum sensing molecules on muscle cells.” (2018)

• Eva Dhondt

“The effects of quorum sensing peptides on mammalian cells.” (2018)

•  Sara Develter

“Solid-phase peptide synthesis of the quorum sensing peptide SDLPFEH and some derivatives.” (2018)

• Hanne Jansen

“Relevance of in vitro and in vivo models to predict human effects in drug cardiovascular safety assessment.” (2018)

• Charlotte Goethals

“CE and MS contribution to E.coli asparaginase analytical characterization.” (2017)

• Vincent Van Brussel

“Viscosity of a hydrocortisone ointment: QbD method development and validation - Dermatokinetic study.” (2017)

• Jan Goelen

“Exploring turbidimetry and isothermal microcalorimetry as a tool for susceptibility testing and biofilm research.” (2017)

• Elisa De Pauw

“Optimalisatie van in vitro assays voor het bepalen van de pyrogeniciteit en het hemolytisch potentieel van illegal peptidepreparaten.” (2017)

• Christina Soto Fernandez

“Screening of surface acoustic wave ligand immobilization strategies for E.coli L-asparaginase” (2017)

• Dorien De Swaef

“Solid phase synthesis of possible new selective iNOS-inhibitors.” (2016)

• Sarah Vanwijnsberghe

“Antimicrobial peptides: a study on the influence of D-amino acids on antimicrobial and haemolytic activity.” (2016)

• Evelien De Sutter

“Ontwikkeling van een HILIC-PDA methode voor de detectie van counterfeit peptide biopharmaceuticals.” (2016)

• Jana Vandenbossche

“Optimization of a capillary electrophoresis method for E.Coli L-asparaginase in the context of the charge impurities quantification.” (2016)

• Severine De Craemer

“Exploration of saliva sample preparation techniques for in vivo quorum sensing peptide UHPLC-MS/MS detection.” (2016)

• Julie Cantoro

“Chemical synthesis of COMX_RO-E-2 pheromone containing modified tryptophan.” (2015)

• Laura Verspeelt

“Development of a quality control method for L-asparaginase using capillary electrophoresis.” (2015)

• Janne Catelin

“Synthesis and purification of derivates of a bioactive neuropeptide.” (2015)

• Valerie Van Laere

“High-throughput screening of antimicrobial peptides against Candida krusei and Cryptococcus neoformans.” (2015)

• Lotte Ghijs

“Ontwikkeling van een screeningsmethode voor de detectie van slimming agents en PDE5-inhibitoren in illegale voedingssupplementen met behulp van Phase Optimized Liquid Chromatography (POP-LC).” (2015)

• Charlotte De Vriendt 

“Liquid Chromatography in quality control, quality assurance and bioanalytics of artemisinin derivatives.” (2015)

• Lisa Delahaye 

“Method development and validation of a HS-GC-FID method for the control of residual solvents in salicylic acid.” (2015)

• Valerie Stynen

“Evaluation, qualification and validation of a rapid microbiological method: Biotrak.” (2015)

• Jana Verstraete

“Novel SUB-1 inhibitors as possible antimalaria therapy.” (2015)

• Nathan Debunne

“The synthesis and purification of a number of quorum sensing peptides.” (2015)

• Sven De Troyer:

"Enniatin-containing medicines for topical use: quality-by-design risk assessment of composition variability." (2015)

• Jolien De Waele:

"Development of a bioanalytical uhplc-ms/ms method for NMG in mouse brain." (2015)

• Christoph Portier:

"Initial development of a bioanalytival method for quorum sensing peptides." (2015)

• Martha Donadoni:
  "Quality evaluation of pediatric antimalarial powders for suspension from resource-limited countries." (2015)
• Annelien Sercu:
  "Development of a bio-analytical method for the quantification of N-alkylamides in biological samples using UPLC-MS/MS." (2015)
• Jonas Poppe:
  "Developmental aspects for the quality analysis of selected medicines." (2014)
• Ellen Rogge:
  "Quantitative analysis and practical research of market artemisinin based combination formulations." (2014)
• Stéphanie anderson:
  "Development of a Surface Acoustic Wave method for the functional quality control of selected somatropins." (2014)
• Eline Grauls:
  "API loss during capsule preparation." (2013)
• Karl-Jan Spittaels:
  "Development of a Surface Acoustic Wave method for the functional quality control of selected somatropins." (2013)
• Lieselot Minne:
  "Isolatie en chemische karakterisatie van N-alkylamides uit plantenextracten en hun transdermal gedrag." (2013)
• Flore Vermeersch:
  "Transdermaal onderzoek van twee conanokristal formulaties en twee cyclische depsipeptiden: beauvericine en enniatines." (2013)
• Andy Van Damme:
  "Risk assessment of impurities in topically used excipients: acetol." (2012)
• Laurens Deneve:
  "Toepassingen van Surface Acoustic Wave (SAW) in de farmaceutische wetenschappen." (2012)
• Pieter-Jan Van Bockstal:
  "Een functionele kwaliteitsmonografie voor asparaginase." (2012)
• Matthias Van Laethem:
  "Lipopeptides: column comparison and dry heat stress of polymyxin B sulphate."(2012, ManaMa)
• Maxime Boucart:
  "Clusteren van quorum-sensing signaalpeptiden." (2011)
• Jochem Vancoillie:
  "Vergelijking van methoden voor de activiteitsbepaling van asparaginase."(2011)
• Iris Vandenbroek:
  "Kwantitatieve karakterisatie van het bloed-hersenbarriere (BHB) transport van nieuwe opioid peptiden." (2011)
• Elien Deketelaere:
  "Droge hitte stabiliteit van busereline acetaat d.m.v. een quality-by-design benadering." (2011)
• Wim Demaré:
  "Droge stress stabiliteit van een model peptide mengsel." (2010)
• Celine Thierens:
  "Analytical development of 1,2,4-trioxane derivatives." (2010, ManaMa)
• Elisa Desmet:
  "Fused-core Shell HPLC voor spilanthol, toegepast in transdermaal onderzoek." (2010)
• Daphne Wiskerke:
  "Karakterisatie van NOTA-gemodificeerd somatropine." (2010)
• Ingeborg Wallez:
  "Dejodinatiestudie van gejodieerde obestatine-derivaten." (2010)
• Annelies Van Lerberghe:
  "Chromatografische karakterisatie van peptide: vergelijkende studie van kolommen." (2010)
• Grégoire Bouchez:
  "Development of a new high-throughput method: ion mobility spectrometry versus high performance liquid chromatography." (2010, ManaMa)
• Nele Clottens:
  "Kwaliteitsanalytiek van zalm calcitonine in een nasaal poeder." (2009)
• Eline Halet:
  "Transmembraan gedrag van spilanthol doorheen huid en bucale mucosa." (2009)
• Nathalie Pintelon:
  "Analytische karakterisatie van het bloed-hersen-barriëre transport van 3 opioïde peptides EM-1, EM-2 en CTAP." (2009)
• Sara Vanneste:
  "Transdermaal gedrag van ibuprofen invloed van miconazole nitraat." (2009)
• Cindy Blomme:
  "Gaschromatografie van polyonverzadigde vetzuren." (2008)
• Evelyn De Backer:
  "Karakterisatie van peptide geneesmiddelen: in vitro metabolisatie." (2008)
• Anavarapu Sudhakar:
  "A comparative in-vitro permeation study of testosterone from different commercially available preparations." (2008)
• Céline Thierens:
  "Ion mobility Spectrometry: een bruikbare analytische techniek bij in-vitro transdermale experimenten." (2008)
• Sofie Van Houcke:
  "Kwaliteitscontrole in de karakterisatie van transdermale geneesmiddelen: ontwikkeling van SST voor in vitro FDC huid testen." (2008)
• Jente Boonen:
  "Karakterisatie van transdermale penetratie promotoren." (2007)
• Roosmarijn De Cock:
  "Analyse van dermatologische testosteron preparaten". (2007)
• Nils Stuerebaut:
  "Stress- en radiosterilisatie stabiliteitsonderzoek van enkele geselecteerde peptiden." (2007)
• Sofie Langendries:
  "Bio-analyse van veterinaire drugs: methode-ontwikkeling voor bepaling van roxarsone in veevoeder." (2006)
• Lindsay Van Horebeke:
  

  "Onderzoek naar prevalentie en classificatie van breuklijntabletten." (2006)