Given the complexity and increasing diversity of products and technologies in (bio-)pharmaceuticals processing, it is clear that there will be no “one size fits all” solution for new process development and manufacturing requirements. The research in Pharmaceutical Engineering (PharmaEng) group involves development and application of a digital twin of equipment, processes, and the environment, where functions and properties are treated using various mechanistic frameworks. The research group aims to apply these digital twins to deliver solutions covering all the three aspects of pharmaceutical process development – product design, process design, and process improvement. Modeling frameworks based on first-principles such as DEM, FEM, CFD, and PBM in combination with kinetic, thermodynamic models will be used to design and optimize the system to deliver drug substances and products with desired physical properties.

Our research areas include classical batch and continuous processing unit operations.