Prof. Patrick Sips

• Assistant Professor
• Co-head of the Heritable Thoracic Aortic Disease lab

Contact

Campus UZ, C. Heymanslaan 10, MRB 1 (entrance 34), 9000 Ghent

E-mail   |   LinkedIn    |  UGent Research Explorer   |   ORCID

Personalia

Biography

• 2022 - present: Professor - Ghent University
• 2016 - 2022: Postdoc - Ghent University
• 2013 - 2016: Postdoc -  Brigham and Women's Hospital (Boston)
• 2007 - 2013: Postdoc - Massachusetts General Hospital (Boston)
• 2007: PhD - Ghent University
• 2000: Master Biotechnology - Ghent University

Fun fact

Patrick lived in the USA for nine years and learned to love Boston sports teams as they won national titles in every major American sport during his stay: Red Sox (baseball) in 2007 & 2013, Bruins (ice hockey) in 2011, Patriots (American football) in 2014 & 2016. He even witnessed Game 6 of the 2008 NBA Finals live in the stadium when the Celtics beat the LA Lakers and raised the trophy.

Member of

• Center for Medical Genetics Ghent
• GenTAC Alliance
• Montalcino Aortic Consortium

Research tracks

Expertise

• Using mouse models of Marfan syndrome to understand the mechanisms leading to aortic wall damage
• Studying the effects of fibrillin-1 mutations in different sexes using mice
• Characterization of novel zebrafish models of aortic disease
• High-throughput screening in a zebrafish model of Marfan syndrome
• Implementing genetic variant testing in zebrafish
• Investigating the unfolded protein response in zebrafish

Publications

Key publications

• Loss of zebrafish atp6v1e1b, encoding a subunit of vacuolar ATPase, recapitulates human ARCL type 2C syndrome and identifies multiple pathobiological signatures. (2021) Plos Genetics.
• Bi-allelic premature truncating variants in LTBP1 cause cutis laxa syndrome. (2022) European Journal of Human Genetics.
• Wars2 is a determinant of angiogenesis. (2016) Nature Communications.
• Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy. (2015) Circulation Research.
• The alpha1 isoform of soluble guanylate cyclase regulates cardiac contractility but is not required for ischemic preconditioning. (2011) Basic Research in Cardiology. 

All publications

• Biblio UGent