Connective Tissue Lab

Heritable connective tissue disorders comprise a clinically and genetically heterogeneous group of disorders, mainly characterized by fragility of the skin, ligaments and tendons, bone, the cardiovascular system, eyes and lungs. Although individually rare, together they constitute a significant proportion of genetic diseases.

Research interests

  • Emphasis on following connective tissue disorders:
    • Cutis Laxa
    • Ehlers-Danlos Syndromes
    • Heritable Thoracic Aortic Disease
    • Marfan Syndrome
    • Osteogenesis Imperfecta
    • Pseudoxanthoma Elasticum
  • Multi-omics approaches on patient tissues and cells as well on animal models (zebrafish and mouse)
  • Idenfitication of novel genes for these disease conditions
  • Delineation of potential therapeutic targets in the cellular signaling pathways
  • Search for biomarkers
  • Bridge from fundamental research to clinical applications

More information about the Connective Tissue Lab

More information about Prof. Paul Coucke

More information about Prof. Bert Callewaert

More information about Prof. Fransiska Malfait

More information about Prof. Olivier Vanakker