Functional Paediatric Oncogenomics Lab

Research interests

The lab focuses on neuroblastoma, a childhood solid tumor arising from the sympathetic nervous system with poor prognosis for high-risk patients.

  • Gain insights into the role of genes and signalling networks in initiation and development of childhood cancer
    • by combining high throughput genomic (bulk and single cell) and proteomics technologies, cellular model systems (including organoids), transgenic animal models and human patient derived xenografts in both zebrafish and mice
  • Gain insights into processes leading to treatment resistance as a guide towards precision medicine strategies
    • focus on combination therapies using small molecules and PROTACs (proteolysis targeting chimera) 

More information about the Functional Paediatric Oncogenomics Lab

More information about Prof. Frank Speleman

More information about Prof. Nadine Van Roy