Impact of bedside model-informed precision dosing in special patient populations

Description:

Model-informed precision dosing is a groundbreaking technique in which the knowledge of validated PK/PD models—potentially combined with individually measured biomarkers (e.g., blood levels)—is used to drive advanced dose optimization at the patient’s bedside. This approach holds immense potential to ensure effective treatment right from the start of therapy. In this line of research, we study the clinical benefit and cost-effectiveness of such bedside dosing tools.

The ongoing research is performed in close collaboration with clinicians from the neonatal and pediatric ICU unit (prof. S. Vanhaesebrouck and dr. Evelyn Dhont), the department of Pediatric Hematology, Oncology and Stem Cell Transplantation (Dr. Vicky Bordon) and the department of Internal Medicine and Infectious Diseases (dr. Diana Huis in’t Veld) of the Ghent University Hospital.

Team

• Main supervisor: Prof. Pieter De Cock
• Co-Supervisor: Prof. dr. Peter De Paepe
• PhD student: Apr. Lotte Deschepper