Ghent Precision Dosing Unit

During drug development, pharmaceutical companies primarily focus on "the average patient" with regard to deriving drug dosing regimens. Consequently, drug dosing in special patient populations with altered drug disposition (e.g. children, critically ill, patients on hemodialysis, elderly, cancer patients) frequently remains off-label.
The Ghent Precision Dosing Unit focusses on applied pharmacokinetic/pharmacodynamic (PK/PD) drug research in special patient populations. Ultimate goal is to develop evidence-based tailored dosing regimens. The research is performed in close collaboration with researchers from the hospital pharmacy and clinical departments of the Ghent University Hospital.

Lines of Research

• Impact of Critical Illness on Drug Disposition in Neonates and Children
• Impact of Hemodialysis on Antibiotic Disposition in Adults
• Impact of Age and Frailty on Drug Disposition in Geriatric Adults.
• Impact of bedside model-informed precision dosing in special patient populations
• Accurate assessment of renal function in critically ill children

List of Publications

Recente publicaties gelinkt aan de Ghent precision dosing unit

.

Team

• Supervisor:  , Prof. dr.. Pieter De Cock, Prof. Peter De Paepe
• PhD students: Anh Thi Van Nguyen – Isis Van Herteryck – Arnaud De Clercq – Lotte Deschepper – Evelyn Dhont – Matthias De Langhe
• Researchers: Eline Hermans
• Study coordinator: Anca Amza
• Clinical pharmacologists in training: Loes Van Mierop