Equipment

Synthesis:

  • High Capacity Bohdan Miniblock Synthesizer (modified as automated peptide synthesizer with a Gilson 222XL liquid handler).
  • Radiometer-Copenhagen pH-stat controllers / automated titrators ( PHM82 / TTT80 / ABU80 / REC80).
  • Undatim Ultrasonics: 20000 Hz ultrasonic probe.
  • Fischer 501 Ozone generator.
  • Plas Labs 818 Glove Box for working in oxygen-free and dry conditions.
  • CEM Discover Labmate Microwave oven

Separation and analysis:

  • 2 Varian model 3700 Gas Chromatographs for classic GC and chiral GC analysis.
  • Prep HPLC on a dual Kontron 422 HPLC pump system and a ternary Kontron 525 HPLC pump system with Melz lcd312 RI detector, Kontron 535 UV-VIS detector and Alltech 500 ELSD detector.
  • Agilent technologies 1100 series LC/MSD system (degasser / quaternary pump / autosampler / column oven with column changer / diode array detector / single quad MS detector (VL) with electrospray and APCI source) for classic reversed phase LCMS and chiral HPLC.
  • Varian Cary Eclipse Spectrofluorimeter
  • Hitachi U-2010 UV-VIS spectrophotometer
  • Perkin-Elmer Spectrum1000 FTIR infrared spectrometer with pike-HATR option.
  • Perkin-Elmer 2400 series II elemental analyzer.
  • Parr pressure reactor up to 4 bar : 100 mL - 2 L
  • High pressure reactors (Andreas-Hofer) up to 200 bar : 50 mL - 1 L

Computation & Simulation:

  • Molecular modelling on Silicon Graphics and Intel-Linux workstations:
    • Macromodel 8.1
    • AMBER 10
    • Autodock