Toxicology
Informatie dienstverlening toxicologie
General information
Questions regarding pharmacological problems as well as toxicological analyses should be directed to veterinaire.farmacotoxico@ugent.be or at +32 (0)9 264 73 50.
Toxicology
Following forms can be used to request a toxicological analysis:
We provide qualitative and quantitative detection of several poisonous substances using HPLC-MS/MS or HPLC-UV detection:
- Carbamates and phosphate esters, e.g. aldicarb, carbofuran, parathion
- Coumarines, e.g. coumarine, warfarine, chlorophacinone
- Organochlorated compounds, e.g. lindane
- Heavy metals and metalloids, e.g. copper, lead, arsenic, thallium
- Others: alfa-chloralose, methaldehyde, strychnine, taxus, T-61
Pharmacology
The laboratory is GLP compliant since 2001 for pharmacokinetic and residue studies.
Contract service work includes inter alia
- Safety and residue studies
- Bioavailability studies and pharmacokinetic analysis (compartmental and noncompartmental modeling) with emphasis on absorption, distribution, metabolisation and excretion (ADME) of veterinary drugs and toxic agents
- Residue depletion and withdrawal time calculation according to EMA guidelines (tissues EMEA/CVMP/035/95, milk EMEA/CVMP/473/98)
- Development of HPLC-UV, HPLC-fluorescence and LC-MSn methodology for quantifications of drugs and toxins in biological matrices
- Efficacy testing of mycotoxin binders using a toxicokinetic approach in pigs and broiler chickens
- The use of juvenile pigs as a pediatric preclinical PK/PD model