Prof. dr. Siska Croubels

Prof. dr. Siska Croubels graduated as a pharmacist in 1992 with great honors (UGent). After obtaining her PhD in 1997 in the field of bio-analysis of residues of veterinary drugs in food (Faculty of Pharmaceutical Sciences, UGent), she immediately started her post-doc research at the Laboratory of Pharmacology and Toxicology of the Faculty of Veterinary Medicine (UGent). In 2004, she was appointed as assistant professor of veterinary toxicology at the same faculty. Since 2014, she is full professor and currently head of the Department of Pharmacology, Toxicology and Biochemistry. She is associate member of the European College of Veterinary Pharmacology and Toxicology (ECVPT) and external expert for the FAVV (Federal Agency for the Safety of the Food Chain), Belgian Superior Health Council and BCFI (Belgian Centre for Pharmacotherapeutic Information). She is also member of the Ghent University Research Council (BOF), Industrial Research Fund (IOF) and of several scientific committees of international symposia, such as the International Symposium for Hormone and Veterinary Drug Residue Analysis (VDRA), European Association for Veterinary Pharmacology and Toxicology (EAVPT) and Antimicrobial Agents in Veterinary Medicine (AAVM) conferences. She also serves as an editorial board member for the journal Mycotoxin Research. She is manager of the GLP unit of the department dealing with pharmacokinetic, bio-equivalence and residue studies of drugs.

The main research mission of the Laboratory of Pharmacology and Toxicology (Prof. dr. S. Croubels, Prof. dr. M. Devreese) consists of generating and communicating insights in in vivo ADME processes (absorption, distribution, metabolisation and excretion) and PK/PD modeling of human and veterinary drugs and toxins in a variety of animal species. The Laboratory is OECD GLP compliant for the conduct of in vivo ADME trials, pharmacokinetic modeling, safety studies, and bio-analysis of human and veterinary drugs. The Laboratory has over 20 years of experience in the development of analytical methodologies for the detection and quantification of xenobiotics (drugs, mycotoxins and their metabolites) in different biological samples such as plasma and tissues, using (UHP)LC-MS/MS and HR-LC-MS, and in pharmacokinetic (PK) and toxicokinetic (TK) modeling of these compounds.  The laboratory has 4 (UHP)LC-MS/MS instruments, 1 UHPLC-UV instrument and access to 3 HR-LC-MS instruments.

Doctoral research topics veterinary toxicology

The research within the veterinary toxicology group is related to the mycotoxin problem in livestock. More specifically, bioanalytical method development for quantification in animal matrices; the toxicity, toxicokinetics and residues of (emerging) mycotoxins in livestock; interactions between mycotoxins and pathogens in livestock and models for in vitro and in vivo safety and efficacy testing of mycotoxin detoxifiers. The laboratory is also a member of the interdisciplinary research association group MYTOX.

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Doctoraten en Masterproeven